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Heart Biomarker Evaluation in Apnea Treatment

Name Label Folder
clusterid
Recoded site identifier
Recoded site identifier

The original site identifier was removed from the dataset because it was considered identifiable.

Administrative
followup_visit_date
Date of the follow-up visit
Date of the follow-up visit Administrative
nsrrid
NSRR subject identifier
NSRR subject identifier

This obfuscated subject ID was created by the National Sleep Research Resource (NSRR) team to more easily match with file downloads.

Administrative
timepoint
Visit number
Visit number Administrative
treatmentarm
Treatment Arm
Treatment Arm

1. HLSE (Healthy Lifestyles and Sleep Education - control arm. 2. HLSE-O (Healthy Lifestyles and Sleep Education + (supplemental nocturnal) Oxygen - oxygen arm. 3. HLSE-P (Healthy Lifestyles and Sleep Education + Positive airway pressure treatment -Continuous Positive Airway Pressure (CPAP) arm)

Administrative/Randomization
bmi
Body mass index
Body mass index Anthropometry
heightcm
Height
Height Anthropometry
hipmean
Hip circumference mean (2 measurements)
Hip circumference mean (2 measurements) Anthropometry
neckmean
Neck circumference mean (2 measurements)
Neck circumference mean (2 measurements) Anthropometry
waistmean
Waist circumference mean (2 measurements)
Waist circumference mean (2 measurements) Anthropometry
weightkg
Weight
Weight Anthropometry
diaallmean
Average diastolic pressure
Average diastolic pressure Clinical Data/Vital Signs/Ambulatory Blood Pressure
heartallmean
Average heart rate
Average heart rate Clinical Data/Vital Signs/Ambulatory Blood Pressure
sysallmean
Average systolic pressure
Average systolic pressure Clinical Data/Vital Signs/Ambulatory Blood Pressure
diasmean
Diastolic blood pressure mean (3 measurements)
Diastolic blood pressure mean (3 measurements) Clinical Data/Vital Signs/Seated Blood Pressure
pulsemean
Pulse mean (3 measurements)
Pulse mean (3 measurements) Clinical Data/Vital Signs/Seated Blood Pressure
sysmean
Systolic blood pressure mean (3 measurements)
Systolic blood pressure mean (3 measurements) Clinical Data/Vital Signs/Seated Blood Pressure
agecat
Age category
Age category

Created using values from the calc_age variable

Demographics
calc_age
Age of the participant
Age of the participant Demographics
ethnicity
Ethnicity of the participant
Ethnicity of the participant Demographics
male
Gender of the participant
Gender of the participant Demographics
race7
Race of the participant
Race of the participant Demographics
phqtotal
Patient Health Questionnaire 9: Total Score
Patient Health Questionnaire 9: Total Score

Summary score for Patient Health Questionnaire 9-item. Each item is scored from 0 to 3, while the total score range from 0 to 27. The PHQ-9 score can be divided into the following categories of increasing severity: minimal (0-4), mild (5-9), moderate (10-14), moderately severe (15-19), and severe (20-27). Kroenke K et al. 2001 (PubMED ID: 11556941)

Search for all PHQ-9 variables within this dataset

General Health/Patient Health Questionnaire (PHQ-9)
nsrr_bmi
Body mass index (BMI)
Body mass index (BMI)

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: bmi at Baseline

Harmonized/Anthropometry
nsrr_bp_diastolic
Diastolic blood pressure
Diastolic blood pressure

Average resting diastolic blood pressure of three measurements collected from the upper arm in a single clinic visit. In cases where either of the measurements was missing, the average was calculated discarding the missing value.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: diasmean at Baseline

Harmonized/Clinical Data
nsrr_bp_systolic
Systolic blood pressure
Systolic blood pressure

Average resting systolic blood pressure of three measurements collected from the upper arm in a single clinic visit. In cases where either of the measurements was missing, the average was calculated discarding the missing value.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: sysmean at Baseline

Harmonized/Clinical Data
nsrr_age
Subject age
Subject age

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: calc_age at Baseline

Harmonized/Demographics
nsrr_age_gt89
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: calc_age at Baseline

Harmonized/Demographics
nsrr_ethnicity
Subject ethnicity
Subject ethnicity

Original missing value is recoded as "not reported".

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: ethnicity

Harmonized/Demographics
nsrr_race
Subject race
Subject race

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: race7

Harmonized/Demographics
nsrr_sex
Subject sex
Subject sex

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: male

Harmonized/Demographics
nsrr_current_smoker
Currently smoking cigarettes
Currently smoking cigarettes

Indicates whether subject currently smokes cigarettes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: smoked , smokedmonth at Baseline

Harmonized/Lifestyle and Behavioral Health
nsrr_ever_smoker
Ever smoked cigarettes
Ever smoked cigarettes

Indicates whether subject ever regularly smoked cigarettes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: smoked at Baseline

Harmonized/Lifestyle and Behavioral Health
nsrr_ahi_hp3u
Apnea-Hypopnea Index : (Apneas and hypopneas with >= 3% oxygen desaturation) / hour of sleep
Apnea-Hypopnea Index : (Apneas and hypopneas with >= 3% oxygen desaturation) / hour of sleep

Harmonized by the NSRR team.

Data collected with no EEGs. Refer to the source for detailed definition for respiratory events: ahi_screening at Baseline

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ttldursp_f1
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from home sleep apnea test
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from home sleep apnea test

Estimated sleep duration, providing an approximation of total sleep duration (i.e. total sleep time) inferred from analysis of non-EEG channels Zhao et al., 2017 (PMID:27707441)

Harmonized by the NSRR team. Source: index_time at Baseline

Harmonized/Polysomnography/Sleep Architecture
ahi_screening
Apnea-Hypopnea Index: (Apneas with no oxygen desaturation threshold used + hypopneas with > 50% flow reduction and >= 3% oxygen desaturation) / hours of estimated sleep from type III home sleep apnea test
Apnea-Hypopnea Index: (Apneas with no oxygen desaturation threshold used + hypopneas with > 50% flow reduction and >= 3% oxygen desaturation) / hours of estimated sleep from type III home sleep apnea test

Calculated - Summary metric of sleep disordered breathing events from the baseline screening visit.

Estimated sleep duration, providing an approximation of total sleep duration (i.e. total sleep time) inferred from analysis of non-EEG channels Zhao et al., 2017 (PMID:27707441)

There is a HeartBEAT specific respiratory event index measure aphypi. Details can be found in the Embletta scoring manual.

Sleep Monitoring/Polysomnography/Apnea-Hypopnea Indices
excl05_escore
Epworth Sleepiness Scale score at screening
Epworth Sleepiness Scale score at screening

Calculated - Total score based on an 8-item questionnaires ranking likelihood of dozing off Johns MW 1991 (PubMed ID: 1798888). Scale 0-3 for individual items; 0 to 24 for overall score.

Search for all ESS variables within this dataset

Administrative/Eligibility
exclusion06
Current or past oxygen or Continuous Positive Airway Pressure (CPAP) use
Current or past oxygen or Continuous Positive Airway Pressure (CPAP) use Administrative/Eligibility
incl01_age
Age of participant at screening
Age of participant at screening Administrative/Eligibility
incl04_angio
Established coronary artery disease (CAD): Angiostenosis
Established coronary artery disease (CAD): Angiostenosis Administrative/Eligibility
incl04_bmi30
Coronary artery disease (CAD) risk factors: Body mass index (BMI) greater than 30
Coronary artery disease (CAD) risk factors: Body mass index (BMI) greater than 30 Administrative/Eligibility
incl04_carp
Established coronary artery disease (CAD): Coronary artery revascularization procedure (CARP)
Established coronary artery disease (CAD): Coronary artery revascularization procedure (CARP) Administrative/Eligibility
incl04_diab
Coronary artery disease (CAD) risk factors: Diabetes
Coronary artery disease (CAD) risk factors: Diabetes Administrative/Eligibility
incl04_dyslipid
Coronary artery disease (CAD) risk factors: Dyslipidemia
Coronary artery disease (CAD) risk factors: Dyslipidemia Administrative/Eligibility
incl04_htn
Coronary artery disease (CAD) risk factors: Hypertension (HTN)
Coronary artery disease (CAD) risk factors: Hypertension (HTN) Administrative/Eligibility
incl04_priormi
Established coronary artery disease (CAD): Prior myocardial infarction (MI)
Established coronary artery disease (CAD): Prior myocardial infarction (MI) Administrative/Eligibility
incl05_bscore
Berlin scale score at screening
Berlin scale score at screening Administrative/Eligibility
inclusion04
Established coronary artery disease (CAD) or risk factors
Established coronary artery disease (CAD) or risk factors Administrative/Eligibility
inclusion05
Berlin score greater than 2
Berlin score greater than 2 Administrative/Eligibility
rctsource
Recruitment source
Recruitment source Administrative/Eligibility
cadpresent
Presence of established coronary artery disease (CAD)
Presence of established coronary artery disease (CAD) Administrative/Randomization
bmi_scrn
Body mass index (BMI) at screening visit
Body mass index (BMI) at screening visit

Hand-calculated using self-reported height and weight from the Berlin Questionnaire

Administrative/Screening Visit
adverseevent
Withdrawal Reason: Adverse event or serious adverse event
Withdrawal Reason: Adverse event or serious adverse event Administrative/Withdrawal
ahihigh
Withdrawal Reason: Apnea-Hypopnea Index greater than 50
Withdrawal Reason: Apnea-Hypopnea Index greater than 50 Administrative/Withdrawal
ahilow
Withdrawal Reason: Apnea-Hypopnea Index less than 15
Withdrawal Reason: Apnea-Hypopnea Index less than 15 Administrative/Withdrawal
centap
Withdrawal Reason: Central sleep apnea index greater than 5
Withdrawal Reason: Central sleep apnea index greater than 5 Administrative/Withdrawal
dateofwithdrawal
Withdrawal: Date of withdrawal or removal
Withdrawal: Date of withdrawal or removal Administrative/Withdrawal
dissatisfaction
Withdrawal Reason: Dissatisfaction with treatment
Withdrawal Reason: Dissatisfaction with treatment Administrative/Withdrawal
failpm
Withdrawal Reason: Unable to complete successful portable monitor
Withdrawal Reason: Unable to complete successful portable monitor Administrative/Withdrawal
illness
Withdrawal Reason: Significant concurrent illness
Withdrawal Reason: Significant concurrent illness Administrative/Withdrawal
lastvisit
Withdrawal: Last visit completed
Withdrawal: Last visit completed Administrative/Withdrawal
lossinterest
Withdrawal Reason: Loss of interest in the study
Withdrawal Reason: Loss of interest in the study Administrative/Withdrawal
lostfollowup
Withdrawal Reason: Lost to follow-up
Withdrawal Reason: Lost to follow-up Administrative/Withdrawal
noncompliance
Withdrawal Reason: Protocol non-compliance
Withdrawal Reason: Protocol non-compliance Administrative/Withdrawal
nopm
Withdrawal Reason: Did not wear portable monitor
Withdrawal Reason: Did not wear portable monitor Administrative/Withdrawal
oxysat
Withdrawal Reason: Nocturnal oxygen saturation low
Withdrawal Reason: Nocturnal oxygen saturation low Administrative/Withdrawal
relocation
Withdrawal Reason: Relocation
Withdrawal Reason: Relocation Administrative/Withdrawal
withdrawnconsent
Withdrawal Reason: Withdrawn consent
Withdrawal Reason: Withdrawn consent Administrative/Withdrawal
withother
Withdrawal Reason: Other reason
Withdrawal Reason: Other reason Administrative/Withdrawal
hipcm1
Hip measurement 1
Hip measurement 1 Anthropometry
hipcm2
Hip measurement 2
Hip measurement 2 Anthropometry
neckcm1
Neck measurement 1
Neck measurement 1 Anthropometry
neckcm2
Neck measurement 2
Neck measurement 2 Anthropometry
waistcm1
Waist measurement 1
Waist measurement 1 Anthropometry
waistcm2
Waist measurement 2
Waist measurement 2 Anthropometry
atrfib
Atrial fibrillation
Atrial fibrillation Clinical Data/Diagnostic Studies/Electrocardiogram
atrflu
Atrial flutter
Atrial flutter Clinical Data/Diagnostic Studies/Electrocardiogram
atrialenl
Atrial enlargement
Atrial enlargement Clinical Data/Diagnostic Studies/Electrocardiogram
avcondis
Atrioventricular conduction disturbance
Atrioventricular conduction disturbance Clinical Data/Diagnostic Studies/Electrocardiogram
earlyrep
Early repolarization
Early repolarization Clinical Data/Diagnostic Studies/Electrocardiogram
ecgcomments_text
Comments
Comments Clinical Data/Diagnostic Studies/Electrocardiogram
ectopy
Ectopy
Ectopy Clinical Data/Diagnostic Studies/Electrocardiogram
hypertro
Hypertrophy
Hypertrophy Clinical Data/Diagnostic Studies/Electrocardiogram
infarct
Infarct
Infarct Clinical Data/Diagnostic Studies/Electrocardiogram
ischant
Ischemia: anterior wall
Ischemia: anterior wall Clinical Data/Diagnostic Studies/Electrocardiogram
ischinf
Ischemia: inferior wall
Ischemia: inferior wall Clinical Data/Diagnostic Studies/Electrocardiogram
ischlat
Ischemia: lateral wall
Ischemia: lateral wall Clinical Data/Diagnostic Studies/Electrocardiogram
ischmore
Ischemia: more than one pattern
Ischemia: more than one pattern Clinical Data/Diagnostic Studies/Electrocardiogram
ischnone
Ischemia: none
Ischemia: none Clinical Data/Diagnostic Studies/Electrocardiogram
normrhythm
Normal sinus rhythm
Normal sinus rhythm Clinical Data/Diagnostic Studies/Electrocardiogram
oldinfarct
Old infarct
Old infarct Clinical Data/Diagnostic Studies/Electrocardiogram
pacemaker
Pacemaker
Pacemaker Clinical Data/Diagnostic Studies/Electrocardiogram
paxis
P axis
P axis

Average direction of electrical activity during the P wave

Clinical Data/Diagnostic Studies/Electrocardiogram
pdur
P wave duration
P wave duration

Duration of atrial depolarization

Clinical Data/Diagnostic Studies/Electrocardiogram
printerval
PR interval
PR interval

Duration from the beginning of the P-wave to the beginning of the QRS complex

Clinical Data/Diagnostic Studies/Electrocardiogram
qrsaxis
QRS axis
QRS axis

Average direction of electrical activity during the QRS complex

Clinical Data/Diagnostic Studies/Electrocardiogram
qrsdur
QRS complex duration
QRS complex duration

duration from the end of the PR interval to the end of the S wave

Clinical Data/Diagnostic Studies/Electrocardiogram
qrsivcd
Intraventricular conduction delay
Intraventricular conduction delay

QRS complex wider than .12 seconds

Clinical Data/Diagnostic Studies/Electrocardiogram
qrslbbb
Left bundle branch block
Left bundle branch block

QRS complex wider than .12 seconds

Clinical Data/Diagnostic Studies/Electrocardiogram
qrsnone
QRS conduction block: none
QRS conduction block: none Clinical Data/Diagnostic Studies/Electrocardiogram