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Heart Biomarker Evaluation in Apnea Treatment

What

Multi-center Phase II randomized controlled trial that evaluates the effects of supplemental nocturnal oxygen or Positive Airway Pressure (PAP) therapy.

Who

318 adults aged 45-75 with coronary artery disease or risk factors.

When

2010-2012, subjects had two visits – baseline and 3-month follow-up.

Funding

National Heart, Lung, and Blood Institute and the National Center for Research Resources.

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About the Study

The Heart Biomarker Evaluation in Apnea Treatment (HeartBEAT) is a multi-center Phase II randomized controlled trial that evaluates the effects of supplemental nocturnal oxygen or Positive Airway Pressure (PAP) therapy, compared to optimal medical preventive therapy, over a 3 month intervention period in patients with cardiovascular disease (CVD) or CVD risk factors and moderate to severe obstructive sleep apnea (Apnea-Hypopnea Index 15 to 50). The study's primary outcome is 24 hour blood pressure profile.

Read more about HeartBEAT at ClinicalTrials.gov (NCT01086800).

Dataset Download

/datasets (introduction)
Phenotype data from the baseline and followup visits

/polysomnography (introduction)
Overnight polysomnography (PSG) data using the Embletta Gold device

Protocols and Manuals

Equipment

Recent Changes

Citation

When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.
  3. Gottlieb DJ, Punjabi NM, Mehra R, Patel SR, Quan SF, Babineau DC, Tracy RP, Rueschman M, Blumenthal RS, Lewis EF, Bhatt DL, Redline S. CPAP versus oxygen in obstructive sleep apnea. N Engl J Med. 2014 Jun 12;370(24):2276-85. doi: 10.1056/NEJMoa1306766. PubMed PMID: 24918372; PubMed Central PMCID: PMC4172401.
National Sleep Research Resource
Heart Biomarker Evaluation in Apnea Treatment
https://doi.org/10.25822/njzh-dk37