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Study of Osteoporotic Fractures

Name Label Folder
gender
Gender
Gender Administrative
nsrrid
NSRR Subject Identifier
NSRR Subject Identifier

This identifer links the subject's data and files.

Administrative
sofid
Study of Osteoporotic Fractures (SOF) Public Data Release ID
Study of Osteoporotic Fractures (SOF) Public Data Release ID

The identifier used to link SOF datasets and polysomnography files.

Administrative
v8lbpdia
Diastolic blood pressure (DBP) sitting down (Visit 8)
Diastolic blood pressure (DBP) sitting down (Visit 8) Blood Pressure (BP)
v8lbpsys
Systolic blood pressure (SBP) sitting down (V8)
Systolic blood pressure (SBP) sitting down (V8) Blood Pressure (BP)
nsrr_bmi
Body mass index (BMI)
Body mass index (BMI)

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8bmi at Visit 8

Harmonized/Anthropometry
nsrr_bp_diastolic
Diastolic blood pressure
Diastolic blood pressure

Resting diastolic blood pressure from the upper arm. Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8lbpdia at Visit 8

Harmonized/Clinical Data
nsrr_bp_systolic
Systolic blood pressure
Systolic blood pressure

Resting systolic blood pressure collected from the upper arm. Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8lbpsys at Visit 8

Harmonized/Clinical Data
nsrr_age
Subject age
Subject age

Participant ages greater than 89 have been recoded into 90 for de-identification purposes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8age at Visit 8

Harmonized/Demographics
nsrr_age_gt89
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years

All ages greater than 89 have been recoded to 90. Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8age at Visit 8

Harmonized/Demographics
nsrr_race
Subject race
Subject race

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: race at Visit 8

Harmonized/Demographics
nsrr_sex
Subject sex
Subject sex

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: gender

Harmonized/Demographics
nsrr_current_smoker
Currently smoking cigarettes
Currently smoking cigarettes

Indicates whether subject currently smokes cigarettes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8smok at Visit 8

Harmonized/Lifestyle and Behavioral Health
nsrr_ahi_hp3r_aasm15
Apnea-Hypopnea Index : (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction and >= 3% oxygen desaturation or with arousal) / hour of sleep
Apnea-Hypopnea Index : (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction and >= 3% oxygen desaturation or with arousal) / hour of sleep

Harmonized by the NSRR team.

The definition for hypopneas is consistent with the following clinical guidelines: (1) American Academy of Sleep Medicine (AASM) 2007 Manual (2012 update) (recommended). Berry RB et al. 2012 (PubMed ID:23066376), and (2) American Academy of Sleep Medicine (AASM) 2015 (recommended) [Berry RB et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2. American Academy of Sleep Medicine, Darien, IL, 2015.]

Refer to the source for detailed definition for respiratory events: ahi_a0h3a at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_hp3u
Apnea-Hypopnea Index : (All apneas + hypopneas with >= 3% oxygen desaturation) / hour of sleep
Apnea-Hypopnea Index : (All apneas + hypopneas with >= 3% oxygen desaturation) / hour of sleep

Harmonized by the NSRR team. Refer to the source for detailed definition for respiratory events: ahi_a0h3 at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_hp4r
Apnea-Hypopnea Index : (All apneas + hypopneas with >= 4% oxygen desaturation or with arousal) / hour of sleep
Apnea-Hypopnea Index : (All apneas + hypopneas with >= 4% oxygen desaturation or with arousal) / hour of sleep

Harmonized by the NSRR team. Refer to the source for detailed definition for respiratory events: ahi_a0h4a at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_hp4u_aasm15
Apnea-Hypopnea Index : (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction with >= 4% oxygen desaturation) / hour of sleep
Apnea-Hypopnea Index : (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction with >= 4% oxygen desaturation) / hour of sleep

Harmonized by the NSRR team.

The definition of hypopnea events is consistent with the following clinical guidelines: (1) AASM 2012 update (alternative) Berry RB et al. 2012 (PubMed ID:23066376), and (2) AASM 2015 (acceptable) [Berry RB et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2. American Academy of Sleep Medicine, Darien, IL, 2015.].

Refer to the source for detailed definition for respiratory events: ahi_a0h4 at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_phrnumar_f1
Arousal Index: Number of arousals per hour of sleep from polysomnography
Arousal Index: Number of arousals per hour of sleep from polysomnography

Harmonized by the NSRR team. Source: ai_all at Visit 8

Harmonized/Polysomnography/Arousal
nsrr_flag_spsw
Study scored sleep/wake rather than with full sleep staging if there is not sufficient quality on EEG lead. Studies scored as sleep wake have all sleep stages scored using a default of Stage 2 and no arousals are scored.
Study scored sleep/wake rather than with full sleep staging if there is not sufficient quality on EEG lead. Studies scored as sleep wake have all sleep stages scored using a default of Stage 2 and no arousals are scored.

Harmonized by the NSRR team. Source: slewake at Visit 8

Harmonized/Polysomnography/Signal Quality
nsrr_ttldursp_f1
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from polysomnography
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from polysomnography

Conventionally, this would be called total sleep time (TST) (i.e. total time spent in stage 1 or greater).

Harmonized by the NSRR team. Source: slpprdp at Visit 8

Harmonized/Polysomnography/Sleep Architecture
ai_all
Arousal Index
Arousal Index

Total number of arousals per hour of sleep. Ratio of count of arousals to total sleep time in hours.

Polysomnography (PSG)/Arousals
avgsat
Average oxygen saturation (SaO2) in sleep
Average oxygen saturation (SaO2) in sleep Polysomnography (PSG)/Oxygen Saturation (SaO2)
minsat
Minimum oxygen saturation (SaO2) in sleep
Minimum oxygen saturation (SaO2) in sleep

Lowest oxygen saturation (SaO2)% during sleep

Polysomnography (PSG)/Oxygen Saturation (SaO2)
longap
Longest apnea
Longest apnea Polysomnography (PSG)/Respiratory Events/Apnea
oavgdur
Average obstructive apnea length, entire recording
Average obstructive apnea length, entire recording Polysomnography (PSG)/Respiratory Events/Apnea/Obstructive
longhyp
Longest hypopnea, entire recording
Longest hypopnea, entire recording Polysomnography (PSG)/Respiratory Events/Hypopnea
ahi_a0h3
Apnea-Hypopnea Index (AHI) >= 3% - number of [all apneas] and [hypopneas with >= 3% oxygen desaturation] per hour of sleep
Apnea-Hypopnea Index (AHI) >= 3% - number of [all apneas] and [hypopneas with >= 3% oxygen desaturation] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_a0h3a
Apnea-Hypopnea Index (AHI) >= 3% - number of [all apneas] and [hypopneas with >= 3% oxygen desaturation or arousal] per hour of sleep
Apnea-Hypopnea Index (AHI) >= 3% - number of [all apneas] and [hypopneas with >= 3% oxygen desaturation or arousal] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_a0h4
Apnea-Hypopnea Index (AHI) >= 4% - number of [all apneas] and [hypopneas with >= 4% oxygen desaturation] per hour of sleep
Apnea-Hypopnea Index (AHI) >= 4% - number of [all apneas] and [hypopneas with >= 4% oxygen desaturation] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_a0h4a
Apnea-Hypopnea Index (AHI) >= 4% - number of [all apneas] and [hypopneas with >= 4% oxygen desaturation or arousal] per hour of sleep
Apnea-Hypopnea Index (AHI) >= 4% - number of [all apneas] and [hypopneas with >= 4% oxygen desaturation or arousal] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_c0h3
Central Apnea-Hypopnea Index (CAHI) >= 3% - number of [central apneas] and [hypopneas with >= 3% oxygen desaturation] per hour of sleep
Central Apnea-Hypopnea Index (CAHI) >= 3% - number of [central apneas] and [hypopneas with >= 3% oxygen desaturation] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_c0h3a
Central Apnea-Hypopnea Index (CAHI) >= 3% - number of [central apneas] and [hypopneas with >= 3% oxygen desaturation or arousal] per hour of sleep
Central Apnea-Hypopnea Index (CAHI) >= 3% - number of [central apneas] and [hypopneas with >= 3% oxygen desaturation or arousal] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_c0h4
Central Apnea-Hypopnea Index (CAHI) >= 4% - number of [central apneas] and [hypopneas with >= 4% oxygen desaturation] per hour of sleep
Central Apnea-Hypopnea Index (CAHI) >= 4% - number of [central apneas] and [hypopneas with >= 4% oxygen desaturation] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_c0h4a
Central Apnea-Hypopnea Index (CAHI) >= 4% - number of [central apneas] and [hypopneas with >= 4% oxygen desaturation or arousal] per hour of sleep
Central Apnea-Hypopnea Index (CAHI) >= 4% - number of [central apneas] and [hypopneas with >= 4% oxygen desaturation or arousal] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_o0h3
Obstructive Apnea-Hypopnea Index (OAHI) >= 3% - number of [obstructive apneas] and [hypopneas with >= 3% oxygen desaturation] per hour of sleep
Obstructive Apnea-Hypopnea Index (OAHI) >= 3% - number of [obstructive apneas] and [hypopneas with >= 3% oxygen desaturation] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_o0h3a
Obstructive Apnea-Hypopnea Index (OAHI) >= 3% - number of [obstructive apneas] and [hypopneas with >= 3% oxygen desaturation or arousal] per hour of sleep
Obstructive Apnea-Hypopnea Index (OAHI) >= 3% - number of [obstructive apneas] and [hypopneas with >= 3% oxygen desaturation or arousal] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_o0h4
Obstructive Apnea-Hypopnea Index (OAHI) >= 4% - number of [obstructive apneas] and [hypopneas with >= 4% oxygen desaturation] per hour of sleep
Obstructive Apnea-Hypopnea Index (OAHI) >= 4% - number of [obstructive apneas] and [hypopneas with >= 4% oxygen desaturation] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
ahi_o0h4a
Obstructive Apnea-Hypopnea Index (OAHI) >= 4% - number of [obstructive apneas] and [hypopneas with >= 4% oxygen desaturation or arousal] per hour of sleep
Obstructive Apnea-Hypopnea Index (OAHI) >= 4% - number of [obstructive apneas] and [hypopneas with >= 4% oxygen desaturation or arousal] per hour of sleep Polysomnography (PSG)/Respiratory Events/Indexes
cai0p
Central Apnea Index (CAI) all oxygen desaturations
Central Apnea Index (CAI) all oxygen desaturations Polysomnography (PSG)/Respiratory Events/Indexes
oai0p
Obstructive Apnea Index (OAI) all oxygen desaturations
Obstructive Apnea Index (OAI) all oxygen desaturations Polysomnography (PSG)/Respiratory Events/Indexes
rdi0p
Overall Respiratory Disturbance Index (RDI) all oxygen desaturations
Overall Respiratory Disturbance Index (RDI) all oxygen desaturations Polysomnography (PSG)/Respiratory Events/Indexes
rdi3p
Overall Respiratory Disturbance Index (RDI) at >= 3% oxygen desaturation
Overall Respiratory Disturbance Index (RDI) at >= 3% oxygen desaturation

[(total number of apneas and hypopneas associated with >= 3% oxygen desaturation) / (hours of sleep)]

Polysomnography (PSG)/Respiratory Events/Indexes
rdi3pa
Overall Respiratory Disturbance Index (RDI) at >= 3% oxygen desaturation or arousal
Overall Respiratory Disturbance Index (RDI) at >= 3% oxygen desaturation or arousal

[(total number of apneas and hypopneas with >= 3% oxygen desaturation or arousal) / (hours of sleep)]

Polysomnography (PSG)/Respiratory Events/Indexes
rdi4p
Overall Respiratory Disturbance Index (RDI) at >= 4% oxygen desaturation
Overall Respiratory Disturbance Index (RDI) at >= 4% oxygen desaturation

Ratio of the count of all apneas (central and obstructive) and hypopneas associated with at least a >= 4% oxygen desaturation to the total sleep time expressed in hours

Polysomnography (PSG)/Respiratory Events/Indexes
overall
Overall study grade
Overall study grade Polysomnography (PSG)/Signal Quality
oximdur
Hours of usable oximetry
Hours of usable oximetry Polysomnography (PSG)/Signal Quality
quoxim
Quality of oximetry
Quality of oximetry Polysomnography (PSG)/Signal Quality
slp_eff
Sleep Efficiency
Sleep Efficiency

Percentage of time in bed that was spent sleeping, or the ratio of total sleep time to total time in bed, expressed as a percentage.

Polysomnography (PSG)/Sleep Architecture
slpprdp
Total sleep time
Total sleep time Polysomnography (PSG)/Sleep Architecture
slptime
Total sleep time
Total sleep time Polysomnography (PSG)/Sleep Architecture
noplm
Number of periodic limb movements (PLMs) during sleep
Number of periodic limb movements (PLMs) during sleep Polysomnography (PSG)/Sleep Events
plmaslp
Total number of periodic limb movements (PLMs) with arousal (in all sleep)
Total number of periodic limb movements (PLMs) with arousal (in all sleep) Polysomnography (PSG)/Sleep Events/Limb Movements
posn
Position sensor working
Position sensor working

1=Position sensor working

Polysomnography (PSG)/Sleep Events/Limb Movements
age_category
Age (categorical)
Age (categorical) Administrative
race
Race
Race Administrative
v8age
Age of participant
Age of participant

Participant ages greater than 89 have been recoded into 90 for de-identification purposes.

Administrative
v8folall
Overall follow-up time since visit 8
Overall follow-up time since visit 8 Administrative
visit
Visit number
Visit number

The Study of Osteoporotic Fractures (SOF) Visit where the data were collected/derived.

Administrative
v4hipg
Hip
Hip

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Anthropometry
v4wais
Waist
Waist

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Anthropometry
v4wsthip
Waist to hip ratio
Waist to hip ratio

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Anthropometry
v8bmi
Body Mass Index (BMI)
Body Mass Index (BMI) Anthropometry
v8hght
Height
Height Anthropometry
v8wght
Weight
Weight Anthropometry
v1lbppls
Pulse lying down
Pulse lying down

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v1lidias
Diastolic blood pressure (DBP) lying down
Diastolic blood pressure (DBP) lying down

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v1lisys
Systolic blood pressure (SBP) lying down
Systolic blood pressure (SBP) lying down

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v1sbppls
Pulse standing
Pulse standing

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v1stddia
Diastolic blood pressure (DBP) standing up
Diastolic blood pressure (DBP) standing up

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v1stdsys
Systolic blood pressure (SBP) standing up
Systolic blood pressure (SBP) standing up

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v8ppls
Average pulse
Average pulse Blood Pressure (BP)
v9sitdia
Diastolic blood pressure (DBP) sitting down (Visit 9)
Diastolic blood pressure (DBP) sitting down (Visit 9)

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v9sitsys
Systolic blood pressure (SBP) sitting down (Visit 9)
Systolic blood pressure (SBP) sitting down (Visit 9)

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Blood Pressure (BP)
v8brstca
Indicators of occurrence of breast cancer
Indicators of occurrence of breast cancer Endpoints
v8dthash
Atherosclerosis cardio death
Atherosclerosis cardio death Endpoints
v8dthchd
Ischemic heart disease (IHD) death
Ischemic heart disease (IHD) death Endpoints
v8dthstk
Stroke death
Stroke death Endpoints
v8dthsud
Ischemic heart disease (IHD) and sudden death
Ischemic heart disease (IHD) and sudden death Endpoints
v1diabcl
Diabetes with insulin info
Diabetes with insulin info

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Lifestyle
v1drink
In the past 12 months, have you had at least one drink of any kind of alcoholic beverage?
In the past 12 months, have you had at least one drink of any kind of alcoholic beverage?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Lifestyle
v1drwka
Drinks per week adjusted for atypical drinking
Drinks per week adjusted for atypical drinking

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Lifestyle
v8dr30
During the last 30 days, have you had at least one drink of any kind of alcoholic beverage? (Including beer, wine, or mixed drinks such as martinis or manhattans.)
During the last 30 days, have you had at least one drink of any kind of alcoholic beverage? (Including beer, wine, or mixed drinks such as martinis or manhattans.) Lifestyle
v8drwk30
Which one of these statements comes closest to describing how often you drank any alcoholic beverages in the last 30 days?
Which one of these statements comes closest to describing how often you drank any alcoholic beverages in the last 30 days? Lifestyle
v8smok
Do you currently smoke cigarettes?
Do you currently smoke cigarettes? Lifestyle
v1hyten
Hypertension status
Hypertension status

Defined by systolic blood pressure > 160, diastolic blood pressure > 90, or use of thiazides. This variable was collected at a different timepoint than the 'Visit 8' sleep variables.

Medical History
v2echf
Has a doctor ever told you that you have congestive heart failure (CHF)?
Has a doctor ever told you that you have congestive heart failure (CHF)?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v2enghrt
Has a doctor ever told you that you have an enlarged heart?
Has a doctor ever told you that you have an enlarged heart?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v4ekg
Has a doctor ever told you that you have an abnormal EKG, ECG, or electrocardiogram?
Has a doctor ever told you that you have an abnormal EKG, ECG, or electrocardiogram?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v4hrtdtx
Are you currently being treated for this condition by a doctor?
Are you currently being treated for this condition by a doctor?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v4seiz
Has a doctor ever told you that you have seizures (fits or convulsions)?
Has a doctor ever told you that you have seizures (fits or convulsions)?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v5scancr
In the last two years, has a doctor told you that you have cancer?
In the last two years, has a doctor told you that you have cancer?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6sangin
Has a doctor or other health care provider ever told you that you had angina?
Has a doctor or other health care provider ever told you that you had angina?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6scong
Has a doctor or other health care provider ever told you that you have congestive heart failure (CHF), enlarged heart?
Has a doctor or other health care provider ever told you that you have congestive heart failure (CHF), enlarged heart?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6scopd
Has a doctor or other health care provider ever told you that you have chronic obstructive lung disease (COPD), chronic bronchitis, asthma, emphysema?
Has a doctor or other health care provider ever told you that you have chronic obstructive lung disease (COPD), chronic bronchitis, asthma, emphysema?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6sdepr
Has a doctor or other health care provider ever told you that you have depression?
Has a doctor or other health care provider ever told you that you have depression?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6sdiab
Has a doctor or other health care provider ever told you that you have diabetes?
Has a doctor or other health care provider ever told you that you have diabetes?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6sheart
Has a doctor or other health care provider ever told you that you had a heart attack, coronary, or myocardial infarction (MI)?
Has a doctor or other health care provider ever told you that you had a heart attack, coronary, or myocardial infarction (MI)?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6shyper
Has a doctor or other health care provider ever told you that you have high blood pressure?
Has a doctor or other health care provider ever told you that you have high blood pressure?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6sohrt
Has a doctor or other health care provider ever told you that you have other heart disease?
Has a doctor or other health care provider ever told you that you have other heart disease?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History
v6sstrk
Has a doctor or other health care provider ever told you that you had a stroke?
Has a doctor or other health care provider ever told you that you had a stroke?

This variable was collected at a different timepoint than the 'Visit 8' sleep variables

Medical History