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Study of Osteoporotic Fractures


Multi-center study originally focused on risk factors for fractures and falls and has grown to look at various determinants of successful aging.


Women ages 65-89 years


Sleep visit took place between 2002 and 2003


National Institutes of Health


The multi-center Study of Osteoporotic Fractures (SOF) has 16 years of prospective data about osteoporosis that has served as the basis for many findings about osteoporosis and aging in women age 65 or older. In addition to adjudication of fractures, SOF has tracked cases of incident breast cancer, stroke, and total and cause-specific mortality. The data include serial measures of bone mineral density, measurements of sex and calcitropic hormones, tests of strength and function, cognitive exams, use of medication, health habits and much more.

The SOF Online website was created in 2011 in order to open the SOF data to the broader research community. In collaboration with SOF Online, the National Sleep Research Resource is making available the SOF raw sleep study (EDF) data, along with a fuller set of polysomnography variables. Sleep studies were completed on 461 SOF participants at Visit 8.

Data overview

/datasets (introduction)
Core data from SOF Visit 8 sleep examination and key measures from other visits.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from Visit 8.

Protocols and manuals


Recent changes



When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.
  3. Cummings SR, Black DM, Nevitt MC, Browner WS, Cauley JA, Genant HK, Mascioli SR, Scott JC, Seeley DG, Steiger P, et al. Appendicular bone density and age predict hip fracture in women. The Study of Osteoporotic Fractures Research Group. JAMA. 1990 Feb 2;263(5):665-8. PubMed PMID: 2404146.
  4. Spira AP, Blackwell T, Stone KL, Redline S, Cauley JA, Ancoli-Israel S, Yaffe K. Sleep-disordered breathing and cognition in older women. J Am Geriatr Soc. 2008 Jan;56(1):45-50. Epub 2007 Nov 28. PubMed PMID: 18047498.
National Sleep Research Resource
Study of Osteoporotic Fractures