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Study of Osteoporotic Fractures

Name Label Folder
nsrr_bmi
Body mass index (BMI)
Body mass index (BMI)

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: "v8bmi: at Visit 8

Harmonized/Anthropometry
nsrr_bp_diastolic
Diastolic blood pressure
Diastolic blood pressure

Resting diastolic blood pressure from the upper arm. Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8lbpdia at Visit 8

Harmonized/Clinical Data
nsrr_bp_systolic
Systolic blood pressure
Systolic blood pressure

Resting systolic blood pressure collected from the upper arm. Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8lbpsys at Visit 8

Harmonized/Clinical Data
nsrr_age
Subject age
Subject age

Participant ages greater than 89 have been recoded into 90 for de-identification purposes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8age at Visit 8

Harmonized/Demographics
nsrr_age_gt89
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years

All ages greater than 89 have been recoded to 90. Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8age at Visit 8

Harmonized/Demographics
nsrr_race
Subject race
Subject race

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: race at Visit 8

Harmonized/Demographics
nsrr_sex
Subject sex
Subject sex

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: gender

Harmonized/Demographics
nsrr_current_smoker
Currently smoking cigarettes
Currently smoking cigarettes

Indicates whether subject currently smokes cigarettes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: v8smok at Visit 8

Harmonized/Lifestyle and Behavioral Health
nsrr_ahi_hp3r_aasm15
Apnea-Hypopnea Index: (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction and >= 3% oxygen desaturation or with arousal) / hour of sleep
Apnea-Hypopnea Index: (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction and >= 3% oxygen desaturation or with arousal) / hour of sleep

Harmonized by the NSRR team.

The definition for hypopneas is consistent with the following clinical guidelines: (1) American Academy of Sleep Medicine (AASM) 2007 Manual (2012 update) (recommended). Berry RB et al. 2012 (PubMed ID:23066376), and (2) American Academy of Sleep Medicine (AASM) 2015 (recommended) [Berry RB et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2. American Academy of Sleep Medicine, Darien, IL, 2015.]

Refer to the source for detailed definition for respiratory events: ahi_a0h3a at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_hp3u
Apnea-Hypopnea Index: (All apneas + hypopneas with >= 3% oxygen desaturation) / hour of sleep
Apnea-Hypopnea Index: (All apneas + hypopneas with >= 3% oxygen desaturation) / hour of sleep

Harmonized by the NSRR team. Refer to the source for detailed definition for respiratory events: ahi_a0h3 at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_hp4r
Apnea-Hypopnea Index: (All apneas + hypopneas with >= 4% oxygen desaturation or with arousal) / hour of sleep
Apnea-Hypopnea Index: (All apneas + hypopneas with >= 4% oxygen desaturation or with arousal) / hour of sleep

Harmonized by the NSRR team. Refer to the source for detailed definition for respiratory events: ahi_a0h4a at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_hp4u_aasm15
Apnea-Hypopnea Index: (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction with >= 4% oxygen desaturation) / hour of sleep
Apnea-Hypopnea Index: (All apneas + hypopneas with >=30% nasal cannula [or alternative sensor] reduction with >= 4% oxygen desaturation) / hour of sleep

Harmonized by the NSRR team.

The definition of hypopnea events is consistent with the following clinical guidelines: (1) AASM 2012 update (alternative) Berry RB et al. 2012 (PubMed ID:23066376), and (2) AASM 2015 (acceptable) [Berry RB et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2. American Academy of Sleep Medicine, Darien, IL, 2015.].

Refer to the source for detailed definition for respiratory events: ahi_a0h4 at Visit 8

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_phrnumar_f1
Arousal Index: Number of arousals per hour of sleep from polysomnography
Arousal Index: Number of arousals per hour of sleep from polysomnography

Harmonized by the NSRR team. Source: ai_all at Visit 8

Harmonized/Polysomnography/Arousal
nsrr_flag_spsw
Study scored sleep/wake rather than with full sleep staging if there is not sufficient quality on EEG lead. Studies scored as sleep wake have all sleep stages scored using a default of Stage 2 and no arousals are scored.
Study scored sleep/wake rather than with full sleep staging if there is not sufficient quality on EEG lead. Studies scored as sleep wake have all sleep stages scored using a default of Stage 2 and no arousals are scored.

Harmonized by the NSRR team. Source: slewake at Visit 8

Harmonized/Polysomnography/Signal Quality
nsrr_pctdursp_s1
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 1 (N1) from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 1 (N1) from polysomnography

Harmonized by the NSRR team. Source: tmstg1p at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_pctdursp_s2
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 2 (N2) from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 2 (N2) from polysomnography

Harmonized by the NSRR team. Source: tmstg2p at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_pctdursp_s3
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 3/4 (N3) from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 3/4 (N3) from polysomnography

Harmonized by the NSRR team. Source: tmstg34p at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_pctdursp_sr
Percentage of total sleep duration (i.e., total sleep time, TST) in REM from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in REM from polysomnography

Harmonized by the NSRR team. Source: tmremp at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttldursp_f1
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from polysomnography
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from polysomnography

Conventionally, this would be called total sleep time (TST) (i.e. total time spent in stage 1 or greater).

Harmonized by the NSRR team. Source: slpprdp at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttldursp_s1s4
REM Sleep Latency: the interval between the first sleep epoch and REM sleep excluding wake
REM Sleep Latency: the interval between the first sleep epoch and REM sleep excluding wake

Harmonized by the NSRR team. Source: remlaiip at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttleffsp_f1
Sleep Efficiency: the ratio of sleep duration (i.e., total sleep time, TST) to in-bed period frompolysomnography
Sleep Efficiency: the ratio of sleep duration (i.e., total sleep time, TST) to in-bed period frompolysomnography

Harmonized by the NSRR team. Source: slp_eff at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttllatsp_f1
Sleep Latency: the interval between lights-out/in-bed time and sleep onset time from polysomnography
Sleep Latency: the interval between lights-out/in-bed time and sleep onset time from polysomnography

Harmonized by the NSRR team. Source: slplatp at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttlprdbd_f1
Total period of bed (i.e., time in bed) from polysomnography
Total period of bed (i.e., time in bed) from polysomnography

Harmonized by the NSRR team. Source: timebedp at Visit 8

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttlprdsp_s1sr
REM Sleep Latency: the interval between the first sleep epoch and REM sleep including wake
REM Sleep Latency: the interval between the first sleep epoch and REM sleep including wake

Harmonized by the NSRR team. Source: remlaip at Visit 8

Harmonized/Polysomnography/Sleep Architecture