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Heart Rate Variability Toolkit

Heart rate variability (HRV) analysis attempts to assess cardiac autonomic regulation through quantification of sinus rhythm variability. The sinus rhythm times series is derived from the QRS to QRS (RR) interval sequence of the electrocardiogram (ECG), by extracting only normal sinus to normal sinus (NN) interbeat intervals. Relatively high frequency variations in sinus rhythm reflect parasympathetic (vagal) modulation, and slower variations reflect a combination of both parasympathetic and sympathetic modulation and non-autonomic factors.

PhysioNet's HRV Toolkit is a rigorously validated package of open source software for HRV analysis, including visualization of NN interval time series, automated outlier removal, and calculation of the basic time- and frequency-domain HRV statistics widely used in the literature.