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MESA- HRV Analysis, Exclusion Criteria

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sara22 +0 points · 8 months ago

I have a general question. I would be interested in what the reason is for the exclusion of certain data from individuals and intervals in the MESA HRV analysis.

In the 'analysis notes' (https://sleepdata.org/datasets/mesa/pages/hrv-analysis.md) I found the following:

  1. Individuals with less than 1,000 normal-to-normal (NN) intervals and/or less than two hours of combined sleep stages REM, N1, N2, N3 and N4 were excluded. 2.NN intervals < 0.35 sec or > 2.5 were excluded.
  2. 5-min windows with less than 180 NN intervals were excluded.

Does this have to do with artefacts? Why did you decide exactly for 0.35, 2.5, 180 and 1000? Are these set empirically by you or based on a paper? I did not find it in Task Force of The European Society of Cardiology and The North American Society of Pacing and Electrophysiology, Heart rate variability (HRV) standards of measurement, physiological interpretation, and clinical use (European Heart Journal, 1996;17:354–81) but maybe I overread it.

I would appreciate if someone has an idea and can help.

Thanks.

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mrueschman +0 points · 8 months ago

Sara,

Thanks for your inquiry. I reached out to the leader of the MESA HRV analysis with some of your questions. I will post again when I hear back.

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Damnit +0 points · 8 months ago

你好,我涉及的是有关于OSAHS方面的,请问标注每个人在某分钟出现呼吸暂停的文件是哪个,就是标注呼吸暂停的标签

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mrueschman +0 points · 8 months ago

Hi Damnit,

The XML annotation files contain timestamped markers for apneas and hypopneas. For SHHS Visit 1, see here - https://sleepdata.org/datasets/shhs/files/polysomnography/annotations-events-profusion/shhs1

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Damnit +0 points · 7 months ago

OK,您说的对我帮助非常大,非常感谢,另外我还想问一下,针对这个XLM注释文件表格里面的一些专业术语的解释在哪个文件,里面有一些专业术语我不懂代表了什么。

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mrueschman +0 points · 7 months ago

The "Polysomnography introduction" pages (e.g. https://sleepdata.org/datasets/shhs/pages/05-polysomnography-introduction.md) have links that describe the XML files.

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Damnit +0 points · 7 months ago

get,非常感谢,您的回答对我的帮助非常大,再次感谢

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mrueschman +0 points · 8 months ago

I received a response from the analyst. Posted below.

Does this have to do with artefacts?

Yes.

Why did you decide exactly for 0.35, 2.5, 180 and 1000? Are these set empirically by you or based on a paper?

They were set empirically.

These thresholds were set empirically with the objective of removing artifacts.

Even though automated QRS annotations were corrected as appropriate by a trained technician, a residual number of beats could have been incorrectly annotated. NN intervals < 0.35 s are artifact because they fall on the refractory period of the heart. There is also a very high chance that NN intervals > 2.5 s (heart rate less than 24 bpm) are misdetections rather then long pauses. These thresholds were meant to exclude misdetections and mislabeled beats.

“180”: 180 beats in 5 minutes corresponds to a heart rate of 36 bpm. If a 5-min window did not have at least 180 beats most likely that was due to artifact and/or the presence of non-sinus beats. For some perspective, the population median [25th and 75th percentiles] of the average NN interval was 939 [859 – 1033] ms, which in terms of heart rate corresponds to 63.9 [58 – 69.8] bpm.

Note that HRV is a technique that only applies to NN interval time series. Furthermore, there is no consensus on how to perform frequency analysis of “discontinuous” (due to the deletion of non-sinus beats) time series. Thus we wanted to limit the number of these windows.

“1000”: Participants with less than 1000 NN intervals (~15 mins) over the full night were immediately excluded. Either they were not in sinus rhythm or signal quality was an issue. Criteria for analyzing participants with at least 2h of combined N1, N2, N3-N4, REM was based on the idea that if we wanted to compare HRV for different sleep stages we needed a minimum amount of data. In addition, for the generation of full night (from sleep onset to sleep termination) summary statistics we wanted to avoid putting together those who spend most of the sleep period awake with those who slept “much more”.

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sara22 +0 points · 8 months ago

Thank you very much. The information helps me a lot.

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