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Study of Osteoporotic Fractures


The multi-center Study of Osteoporotic Fractures (SOF) has 16 years of prospective data about osteoporosis that has served as the basis for many findings about osteoporosis and aging in women age 65 or older. In addition to adjudication of fractures, SOF has tracked cases of incident breast cancer, stroke, and total and cause-specific mortality. The data include serial measures of bone mineral density, measurements of sex and calcitropic hormones, tests of strength and function, cognitive exams, use of medication, health habits and much more.

The SOF Online website was created in 2011 in order to open the SOF data to the broader research community. In collaboration with SOF Online, the National Sleep Research Resource is making available the SOF raw sleep study (EDF) data, along with a fuller set of polysomnography variables. Sleep studies were completed on 461 SOF participants at Visit 8.

Citation and acknowledgement

When using this dataset, please cite the following:

Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358. doi: 10.1093/jamia/ocy064. PMID: 29860441; PMCID: PMC6188513.

Spira AP, Blackwell T, Stone KL, Redline S, Cauley JA, Ancoli-Israel S, Yaffe K. Sleep-disordered breathing and cognition in older women. J Am Geriatr Soc. 2008 Jan;56(1):45-50. doi: 10.1111/j.1532-5415.2007.01506.x. Epub 2007 Nov 28. PMID: 18047498.

Please include the following text in the Acknowledgements:

The Study of Osteoporotic Fractures (SOF) was supported by National Institutes of Health grants (AG021918, AG026720, AG05394, AG05407, AG08415, AR35582, AR35583, AR35584, RO1 AG005407, R01 AG027576-22, 2 R01 AG005394-22A1, 2 RO1 AG027574-22A1, HL40489, T32 AG000212-14). The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).

Data overview

/datasets (introduction)
Core data from SOF Visit 8 sleep examination and key measures from other visits.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from Visit 8.

Protocols and manuals


Recent changes

National Sleep Research Resource
Study of Osteoporotic Fractures