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MrOS Sleep Study


Ancillary study that focuses on understanding the relationship between sleep disorders and falls, fractures, mortality, and vascular disease.


2,911 men 65 years or older.


Two sleep study cycles, 2003-2005 and 2009-2012.


National Institutes of Health

About the Study

MrOS is an ancillary study of the parent Osteoporotic Fractures in Men Study. Between 2000 and 2002, 5,994 community-dwelling men 65 years or older were enrolled at 6 clinical centers in a baseline examination. Between December 2003 and March 2005, 3,135 of these participants were recruited to the Sleep Study when they underwent full unattended polysomnography and 3 to 5-day actigraphy studies. The objectives of the Sleep Study are to understand the relationship between sleep disorders and falls, fractures, mortality, and vascular disease.

The MrOS dataset on NSRR is limited in scope (e.g. no actigraphy raw data or results are included), with its primary focus being polysomnography (PSG) data. MrOS Online is a publicly available resource that contains additional sleep variables and data from other MrOS research visits. For more information on the MrOS cohort, contact the San Francisco Coordinating Center.

Data overview

/datasets (introduction)
Core data from MrOS Sleep Visit 1 and Visit 2.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from MrOS Sleep Visit 1 and Visit 2.

Protocols and Manuals


HRV Analysis

As part of Ancillary Study #108, researchers at Case Western Reserve University performed heart rate variability analysis on MrOS Sleep Visit 1 data. Read more about the methods and browse the result variables.

Recent Changes


When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.
  3. Blank JB, Cawthon PM, Carrion-Petersen ML, Harper L, Johnson JP, Mitson E, Delay RR. Overview of recruitment for the osteoporotic fractures in men study (MrOS). Contemp Clin Trials. 2005 Oct;26(5):557-68. PubMed PMID: 16085466.
  4. Orwoll E, Blank JB, Barrett-Connor E, Cauley J, Cummings S, Ensrud K, Lewis C, Cawthon PM, Marcus R, Marshall LM, McGowan J, Phipps K, Sherman S, Stefanick ML, Stone K. Design and baseline characteristics of the osteoporotic fractures in men (MrOS) study--a large observational study of the determinants of fracture in older men. Contemp Clin Trials. 2005 Oct;26(5):569-85. PubMed PMID: 16084776.
  5. Blackwell T, Yaffe K, Ancoli-Israel S, Redline S, Ensrud KE, Stefanick ML, Laffan A, Stone KL; Osteoporotic Fractures in Men Study Group. Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study. J Am Geriatr Soc. 2011 Dec;59(12):2217-25. doi: 10.1111/j.1532-5415.2011.03731.x. Epub 2011 Nov 7. PubMed PMID: 22188071; PubMed Central PMCID: PMC3245643.
National Sleep Research Resource
MrOS Sleep Study