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Multi-Ethnic Study of Atherosclerosis


Multi-Ethnic Study of Atherosclerosis (MESA) is an NHLBI-sponsored 6-center collaborative longitudinal investigation of factors associated with the development of subclinical cardiovascular disease and the progression of subclinical to clinical cardiovascular disease in 6,814 black, white, Hispanic, and Chinese-American men and women initially ages 45-84 at baseline in 2000-2002. There have been four follow-up exams to date, in the years 2003-2004, 2004-2005, 2005-2007, and 2010-2011. Between 2010-2012, 2,237 participants also were enrolled in a Sleep Exam (MESA Sleep) which included full overnight unattended polysomnography, 7-day wrist-worn actigraphy, and a sleep questionnaire. The objectives of the sleep study are to understand how variations in sleep and sleep disorders vary across gender and ethnic groups and relate to measures of subclinical atherosclerosis.

MESA Sleep data are made available in collaboration with the MESA Coordinating Center. We have made polysomnography and actigraphy raw data available for download, along with key sets of MESA Sleep covariates. If you wish to access data from other MESA exams, please visit the BioLINCC MESA Collection or contact the MESA Coordinating Center.

Citation and acknowledgement

When using this dataset, please cite the following:

Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358. doi: 10.1093/jamia/ocy064. PMID: 29860441; PMCID: PMC6188513.

Chen X, Wang R, Zee P, Lutsey PL, Javaheri S, Alcántara C, Jackson CL, Williams MA, Redline S. Racial/Ethnic Differences in Sleep Disturbances: The Multi-Ethnic Study of Atherosclerosis (MESA). Sleep. 2015 Jun 1;38(6):877-88. doi: 10.5665/sleep.4732. PMID: 25409106; PMCID: PMC4434554.

Please include the following text in the Acknowledgements:

The Multi-Ethnic Study of Atherosclerosis (MESA) Sleep Ancillary study was funded by NIH-NHLBI Association of Sleep Disorders with Cardiovascular Health Across Ethnic Groups (RO1 HL098433). MESA is supported by NHLBI funded contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by cooperative agreements UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 funded by NCATS. The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).

Data overview

/actigraphy (introduction)
Wrist-worn actigraphy data from the MESA Sleep exam.

/datasets (introduction)
Core data from the MESA Sleep exam.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from the MESA Sleep exam.

Protocols and manuals


Heart Rate Variability (HRV) Analysis

Read about the methods, validation, and results for the NSRR HRV analysis efforts and browse the included variables.

Recent changes

Find a complete list of changes in the CHANGELOG.md

Publication links

National Sleep Research Resource
Multi-Ethnic Study of Atherosclerosis