Multi-Ethnic Study of Atherosclerosis

What

Multi-center longitudinal investigation of factors associated with cardiovascular disease

Who

6,814 black, white, Hispanic, and Chinese-American men and women

When

2000 to present

Funding

National Heart, Lung, and Blood Institute

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About

Multi-Ethnic Study of Atherosclerosis (MESA) is an NHLBI-sponsored 6-center collaborative longitudinal investigation of factors associated with the development of subclinical cardiovascular disease and the progression of subclinical to clinical cardiovascular disease in 6,814 black, white, Hispanic, and Chinese-American men and women initially ages 45-84 at baseline in 2000-2002. There have been four follow-up exams to date, in the years 2003-2004, 2004-2005, 2005-2007, and 2010-2011. Between 2010-2012, 2,237 participants also were enrolled in a Sleep Exam (MESA Sleep) which included full overnight unattended polysomnography, 7-day wrist-worn actigraphy, and a sleep questionnaire. The objectives of the sleep study are to understand how variations in sleep and sleep disorders vary across gender and ethnic groups and relate to measures of subclinical atherosclerosis.

MESA Sleep data are made available in collaboration with the MESA Coordinating Center. We have made polysomnography and actigraphy raw data available for download, along with key sets of MESA Sleep covariates. If you wish to access data from other MESA exams, please visit the BioLINCC MESA Collection or contact the MESA Coordinating Center.

Data overview

/actigraphy (introduction)
Wrist-worn actigraphy data from the MESA Sleep exam.

/datasets (introduction)
Core data from the MESA Sleep exam.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from the MESA Sleep exam.

Protocols and manuals

Equipment

Heart Rate Variability (HRV) Analysis

Read about the methods, validation, and results for the NSRR HRV analysis efforts and browse the included variables.

Recent changes

Find a complete list of changes in the CHANGELOG.md

Publication links

Citation

When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.

MESA is supported by NHLBI funded contracts HHSN268201500003I, N01-HC-95159, N01-HC-95160, N01-HC-95161, N01-HC-95162, N01-HC-95163, N01-HC-95164, N01-HC-95165, N01-HC-95166, N01-HC-95167, N01-HC-95168 and N01-HC-95169 from the National Heart, Lung, and Blood Institute, and by cooperative agreements UL1-TR-000040, UL1-TR-001079, and UL1-TR-001420 funded by NCATS. MESA Sleep was supported by NHLBI R01 L098433.