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Hispanic Community Health Study / Study of Latinos

Name Label Folder
centernum
Participant's Field Center - numeric
Participant's Field Center - numeric

This variable is the field center that was derived from the city of origin.

Administrative
pid
Random BioLINCC ID for LAD
Random BioLINCC ID for LAD Administrative
vnum
Visit Number
Visit Number Administrative
bmi
Body Mass Index (BMI)
Body Mass Index (BMI) Anthropometry
age
Age
Age

This is the age of the participant in years at the time of the participant's clinic visit.

Demographics
gendernum
Gender
Gender

This variable describes the participant's gender.

Demographics
nsrr_bmi
Body mass index (BMI)
Body mass index (BMI)

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: bmi at Visit 1

Harmonized/Anthropometry
nsrr_bp_diastolic
Diastolic blood pressure
Diastolic blood pressure

Average resting diastolic blood pressure of three measurements collected from the upper arm in a single clinic visit. In cases where either of the measurements was missing, the average was calculated discarding the missing value.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: sbpa6 at Visit 1

Harmonized/Clinical Data
nsrr_bp_systolic
Systolic blood pressure
Systolic blood pressure

Average resting systolic blood pressure of three measurements collected from the upper arm in a single clinic visit. In cases where either of the measurements was missing, the average was calculated discarding the missing value.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: sbpa5 at Visit 1

Harmonized/Clinical Data
nsrr_age
Subject age
Subject age

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: age at Visit 1

Harmonized/Demographics
nsrr_age_gt89
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: age at Visit 1

Harmonized/Demographics
nsrr_ethnicity
Subject ethnicity
Subject ethnicity

All subjects are Hispanic or Latino.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards.

Harmonized/Demographics
nsrr_hispanic_subgroup
Subject hispanic subgroup
Subject hispanic subgroup

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: bkgrd1_c7

Harmonized/Demographics
nsrr_race
Subject race
Subject race

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: race

Harmonized/Demographics
nsrr_sex
Subject sex
Subject sex

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: gendernum

Harmonized/Demographics
nsrr_current_smoker
Currently smoking cigarettes
Currently smoking cigarettes

Indicates whether subject currently smokes cigarettes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: current_smoker at Visit 1

Harmonized/Lifestyle and Behavioral Health
nsrr_ever_smoker
Ever smoked cigarettes
Ever smoked cigarettes

Indicates whether subject ever regularly smoked cigarettes.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: cigarette_use

Harmonized/Lifestyle and Behavioral Health
nsrr_ahi_ap3u
Apnea-Hypopnea Index : (Apneas and hypopneas with >= 3% oxygen desaturation) / hour of estimated sleep
Apnea-Hypopnea Index : (Apneas and hypopneas with >= 3% oxygen desaturation) / hour of estimated sleep

Harmonized by the NSRR team.

Data collected with no EEGs. Refer to the source for detailed definition for respiratory events: slpa54 at Visit 1

Harmonized/Polysomnography/Apnea-Hypopnea Indices
nsrr_ahi_ap4u
Apnea-Hypopnea Index : (Apneas and hypopneas with >= 50% nasal cannula [or alternative sensor] reduction with >= 4% oxygen desaturation) / hour of estimated sleep
Apnea-Hypopnea Index : (Apneas and hypopneas with >= 50% nasal cannula [or alternative sensor] reduction with >= 4% oxygen desaturation) / hour of estimated sleep

Harmonized by the NSRR team.

Data collected with no EEGs. Refer to the source for detailed definition for respiratory events: slpa63 at Visit 1

Harmonized/Polysomnography/Apnea-Hypopnea Indices
any_permit
Any permission for public use of data
Any permission for public use of data

Thi variable combines the 3 permission variables to determine whether or not a study participant gave any permission for public use of data.

Administrative
center
Center
Center

This variable is the field center that was derived from the city of origin.

Administrative
commercial_permit
Permission for for-profit use of data
Permission for for-profit use of data

This variable determines whether or not a study participant gave permission for use for for-profit use of study data.

Administrative
consent
Consent to Participate in HCHS\SOL Study
Consent to Participate in HCHS\SOL Study

This variable determines whether or not a study participant consented to participate in the baseline examination study.

Administrative
days_s1m1
Days between HCHS clinic visit and Sueno clinic visit
Days between HCHS clinic visit and Sueno clinic visit Administrative
dna_available
DNA Available
DNA Available

This variable determines whether or not a study participant had blood draws successfully conducted without incidents or problems for tubes 4 and 5 to make DNA available to investigators associated or not associated to HCHS/SOL and specialized laboratories.

Administrative
external_permit
Permission for investigators outside HCHS/SOL
Permission for investigators outside HCHS/SOL

This variable determines whether or not a study participant gave permission for use for investigators outside HCHS/SOL.

Administrative
flag_agege65
Age greater than or equal to 65 or less than 18
Age greater than or equal to 65 or less than 18 Administrative
flag_ahigt50
AHI greater than 50
AHI greater than 50 Administrative
flag_bkgrd
Ineligible Hispanic background for site
Ineligible Hispanic background for site Administrative
flag_monthsgt30
Sueno visit date more than 31+ months since SOL visit
Sueno visit date more than 31+ months since SOL visit Administrative
flag_narc
Narcolepsy diagnosis
Narcolepsy diagnosis Administrative
flag_osa
Treated for OSA
Treated for OSA Administrative
full_afu_eligible
Annual Follow-Up Eligibity (minimum set of forms present)
Annual Follow-Up Eligibity (minimum set of forms present)

This variable defines a participant as meeting all requirements to determine if eligible for annual follow-up.

Administrative
genotyping
Full consent for genotyping
Full consent for genotyping

This variable determines whether or not a study participant fully consented to genotyping for use with investigators associated or not associated to HCHS/SOL and specialized laboratories.

Administrative
np_permit
Permission for non-profit use of data
Permission for non-profit use of data

This variable determines whether or not a study participant gave permission for non-profit use of study data.

Administrative
sueno_eligible
Eligible Sueno participant
Eligible Sueno participant Administrative
cohort
Cohort Year (from Household Address Wave Assignment)
Cohort Year (from Household Address Wave Assignment)

This variable is an indicator of household sample address allocation and distribution for HCHS/SOL recruitment.

Administrative/Study Design
list_cnt
Sample List-level Hispanic Household Frame Counts
Sample List-level Hispanic Household Frame Counts

This variable is the sample design list household frame count variable used in statistical analyses.

Administrative/Study Design
listnum
List Address Record Assigned
List Address Record Assigned

This variable is the sample design variable used in statistical analyses.

Administrative/Study Design
psu_cnt
BG-level Hispanic Household Frame Counts
BG-level Hispanic Household Frame Counts

This variable is the sample design clustering household frame count variable used in statistical analyses.

Administrative/Study Design
psu_id
Primary Sampling Unit ID
Primary Sampling Unit ID

This variable is the sample design clustering variable used in statistical analyses as the cluster variable that is combination of the field center and selected block group identifier.

Administrative/Study Design
strat
Stratification Variable ID
Stratification Variable ID

This variable is the sample design stratification variable used in statistical analyses as the stratum variable that is a combination of field center, Hispanic household proportion, and SES.

Administrative/Study Design
strat_cnt
Stratum-level Hispanic Household Frame Counts
Stratum-level Hispanic Household Frame Counts

This variable is the sample design stratification household frame variable used in statistical analyses.

Administrative/Study Design
weight_final_expanded
Expanded Census 2010 Final Calibrated Trimmed Nonresponse Adjusted Final Weights - Year 1-3 (frozen as of 10/27/2011)
Expanded Census 2010 Final Calibrated Trimmed Nonresponse Adjusted Final Weights - Year 1-3 (frozen as of 10/27/2011)

The calibrated sample weight is the calibrated, trimmed, non-response adjusted reciprocal of a participant's probability of selection into the HCHS/SOL study. The trimmed, nonresponse adjusted sample weights were calibrated using first the 7-category Hispanic Background distribution and then the 12-category age group/gender distribution using the 2010 Decennial Census. This variable is used for analyses purposes only.

Administrative/Study Design
weight_final_norm_center
FC-specific Normalized Census 2010 Calibrated Trimmed NonResponse Adjusted Final Weights - Year 1-3 (frozen as of 10/27/2011)
FC-specific Normalized Census 2010 Calibrated Trimmed NonResponse Adjusted Final Weights - Year 1-3 (frozen as of 10/27/2011)

The FC-specific normalized sample weight is the field center specific normalized, calibrated, trimmed, non-response adjusted (household and person-level) reciprocal of a participant's probability of selection into the HCHS/SOL study. The calibrated, trimmed, non-response adjusted sample weights were normalized using the weighted mean divided by weighted standard deviation calculated for each field center separately and used to normalize the expanded calibrated sample weights (WEIGHT_Final_Norm_Center). This final sample weight variable is used for analyses purposes only when the subpopulation is restricted to within a single site.

Administrative/Study Design
weight_final_norm_overall
Overall Sample Normalized Census 2010 Calibrated Trimmed NonResponse Adjusted Final Weights - Year 1-3 (frozen as of 10/27/2011)
Overall Sample Normalized Census 2010 Calibrated Trimmed NonResponse Adjusted Final Weights - Year 1-3 (frozen as of 10/27/2011)

The normalized sample weight is the overall normalized, calibrated, trimmed, nonresponse adjusted (household and person-level) reciprocal of a participant's probability of selection into the HCHS/SOL study. The base sample weights, i.e. the reciprocal of a participant's probability of selection into the HCHS/SOL study, were first adjusted by household-level and person-level non-response. The non-response adjusted sample weights were then trimmed using the selected average percentile that minimizes model MSE within each field center. All sample weights that fell above the selected percentile were trimmed to the selected percentile and the trimmed difference was evenly distributed among all of the non-trimmed sample weights. The trimmed, non-response adjusted sample weights were then calibrated using first the 7-category Hispanic Background distribution and then the 12-category age group/gender distribution using the 2010 Decennial Census. Finally, these calibrated, trimmed, non-response adjusted sample weights were normalized using the weighted mean divided by weighted standard deviation of the entire HCHS/SOL sample to normalize the expanded calibrated sample weights (WEIGHT_Final_Norm_Overall). This final sample weight variable is used for analyses purposes only.

Administrative/Study Design
weight_norm_overall_sueno
Sueno sampling weight
Sueno sampling weight Administrative/Study Design
bmigrp_c4
4-level grouped Body Mass Index - WHO
4-level grouped Body Mass Index - WHO

This variable is created using the calculated body mass index to define categories based on current WHO (World Health Organization) classifications

Anthropometry
bmigrp_c4_sol_sueno
4-level grouped Body Mass Index - WHO at the Sueno visit using SOL height
4-level grouped Body Mass Index - WHO at the Sueno visit using SOL height

This variable is created using the calculated body mass index to define categories based on current WHO (World Health Organization) classifications

Anthropometry
bmigrp_c6
6-level grouped Body Mass Index - WHO
6-level grouped Body Mass Index - WHO

This variable is created using the calculated body mass index to define categories based on current WHO (World Health Organization) classifications

Anthropometry
bmigrp_c6_sol_sueno
6-level grouped Body Mass Index - WHO at Sueno visit using SOL height
6-level grouped Body Mass Index - WHO at Sueno visit using SOL height

This variable is created using the calculated body mass index to define categories based on current WHO (World Health Organization) classifications

Anthropometry
bmi_sol_sueno
Body Mass Index at the Sueño clinic visit, using the SOL height
Body Mass Index at the Sueño clinic visit, using the SOL height Anthropometry
height
Height (corrected)
Height (corrected)

During two time periods the standing height as measured at the Bronx site was incorrect due to a mis-mounted stadiometer used in measuring all participants. The derived variable was implemented based on a recommendation from the Quality Control subcommittee.

Anthropometry
waist_hip
Waist to Hip Ratio
Waist to Hip Ratio Anthropometry
airflow_limitation
Airflow Limitation (pre FEV1/FVC<70 only)
Airflow Limitation (pre FEV1/FVC<70 only)

This variable is based on the empirical evidence from the spirometry that the ratio of FEV1 to FVC is below the level defined by the ATS as indicative of restricted airflow. Defined only for valid spirometries.

Clinical Data/Diagnostic Studies/Lung Function
airflow_obstruction
Obstructive Lung Disease suspect
Obstructive Lung Disease suspect

This variable is based on the empirical evidence from the spirometry that the ratio of FEV1 to FVC is below the level defined by the ATS as indicative of restricted airflow.

Clinical Data/Diagnostic Studies/Lung Function
asthma_c4
4-level grouped Asthma Status
4-level grouped Asthma Status Clinical Data/Diagnostic Studies/Lung Function
asthma_c4_md
4-level grouped Asthma Status - by MD diagnosis
4-level grouped Asthma Status - by MD diagnosis Clinical Data/Diagnostic Studies/Lung Function
asthma_curr
Current Asthma
Current Asthma Clinical Data/Diagnostic Studies/Lung Function
asthma_curr_md
Currently have asthma with ever MD diagnosis
Currently have asthma with ever MD diagnosis Clinical Data/Diagnostic Studies/Lung Function
asthma_ever
Ever had Asthma (self-report)
Ever had Asthma (self-report) Clinical Data/Diagnostic Studies/Lung Function
asthma_ever_md
Ever had asthma with MD diagnosis
Ever had asthma with MD diagnosis Clinical Data/Diagnostic Studies/Lung Function
asthma_meds
Asthma Med Use - self/scanned (curr asthma by MD diag)
Asthma Med Use - self/scanned (curr asthma by MD diag)

This variable combines scanned/transcribed anti-asthmatic medication use with self-report asthma medication use.

Clinical Data/Diagnostic Studies/Lung Function
bd_response_abs
Bronchodilator Responsive by 15% change
Bronchodilator Responsive by 15% change

This variable is based on the post-bronchodilator measurement of the FEV1. The airflow remains restricted after the administration of albuterol the person did not respond by greater than a 15% improvement over their first measurement. If PRBA29 is not missing and POBA29 is not missing and PRBA29 > 0 then.

Clinical Data/Diagnostic Studies/Lung Function
copd_by_bd
COPD by BD Test
COPD by BD Test

This indicator of COPD is based on the post-bronchodilator measurement of the FEV1 to FVC ratio. The airflow remains restricted after the administration of albuterol.

Clinical Data/Diagnostic Studies/Lung Function
copd_by_bd_allpre
COPD by BD Test (for all valid PRE_BD)
COPD by BD Test (for all valid PRE_BD)

This variable is based on the post-bronchodilator measurement of the FEV1 to FVC ratio. The airflow remains restricted after the administration of albuterol. This variable is also defined for all participants who did not conduct a post-spirometry exam. Defined only for valid spirometries.

Clinical Data/Diagnostic Studies/Lung Function
copd_ever
Self-report of ever had COPD/Emph or CB
Self-report of ever had COPD/Emph or CB Clinical Data/Diagnostic Studies/Lung Function
copd_meds
COPD Med Use - self/scanned (ever COPD by MD diag)
COPD Med Use - self/scanned (ever COPD by MD diag)

This variable combines scanned/transcribed anti-asthmatic medication use with self-report COPD medication use.

Clinical Data/Diagnostic Studies/Lung Function
copd_self
Self-report of ever had COPD/Emph
Self-report of ever had COPD/Emph Clinical Data/Diagnostic Studies/Lung Function
fev1_fvc_ratio
FEV1/FVC Ratio
FEV1/FVC Ratio

This variable is the ratio of forced expiratory volume in one minute (FEV1 ) to forced vital capacity (FVC) expressed as a percentage.

Clinical Data/Diagnostic Studies/Lung Function
mrc_cb
Chronic Productive Cough 3+ mths in 2+ yrs
Chronic Productive Cough 3+ mths in 2+ yrs Clinical Data/Diagnostic Studies/Lung Function
phlegm
Phlegm day/night 3 months in a row
Phlegm day/night 3 months in a row Clinical Data/Diagnostic Studies/Lung Function
pneumonia
Pneumonia
Pneumonia Clinical Data/Diagnostic Studies/Lung Function
postbd_expected
Post-BD Expected (among valid spirometry
Post-BD Expected (among valid spirometry

This variable is a flag for whether a post bronchodilator was expected, based on the premeasurement. A post measurement was expected if the FEV1 to FVC ratio was less than 70% or less than the lower limit of normal for FEV1/FVC%.

Clinical Data/Diagnostic Studies/Lung Function
postbd_prebd_diff
Post(FEV1%pred)-Pre(FEV1%pred)
Post(FEV1%pred)-Pre(FEV1%pred)

This variable is based on the ratio of the measured FEV1 difference from postbronchodilator and pre-bronchodilator exams over the Predicted FEV1 calculated prebronch (both values must be non-missing, and the post-bronchodilator spirometry examinations must be valid).

Clinical Data/Diagnostic Studies/Lung Function
postbd_prebd_diff_gt12_v2
Post(FEV1%pred)-Pre(FEV1%pred)>=12% (pre FEV1/FVC<70 only)
Post(FEV1%pred)-Pre(FEV1%pred)>=12% (pre FEV1/FVC<70 only)

This variable is based on the ratio of the measured FEV1 difference from postbronchodilator and pre-bronchodilator exams over the Predicted FEV1 calculated prebronch (both values must be non-missing, and the post-bronchodilator spirometry examination must be valid) among participants with pre FEV1/FVC<70 only (ignores LLN comparison).

Clinical Data/Diagnostic Studies/Lung Function
valid_spirometry
Valid Spirometry Studies (Pre)
Valid Spirometry Studies (Pre)

This variable is an overall data quality indicator derived by the pulmonary reading center on the adequacy study for use.

Clinical Data/Diagnostic Studies/Lung Function
valid_spirometry_postbd
Valid Spirometry Studies (Post BD)
Valid Spirometry Studies (Post BD)

This variable is an overall data quality indicator derived by the pulmonary reading center on the adequacy study for use.

Clinical Data/Diagnostic Studies/Lung Function
valid_spirometry_postbd_v2
Valid post-spirometry (A-D grading) adjusted for unexpected BDs
Valid post-spirometry (A-D grading) adjusted for unexpected BDs

This variable is a flag for whether a post bronchodilator was valid (grade A-D). Defined only for participants where a post measurement was expected.

Clinical Data/Diagnostic Studies/Lung Function
wheeze_last12
Wheezing in last 12 months
Wheezing in last 12 months Clinical Data/Diagnostic Studies/Lung Function
wheeze_sb
Wheezing ever with shortness of breath
Wheezing ever with shortness of breath Clinical Data/Diagnostic Studies/Lung Function
digitsymbol
Digit Symbo Substitution Score (NEEA14)
Digit Symbo Substitution Score (NEEA14)

This variable is for the score of the digit symbol substitution test. Only defined for participants who took a neurocognitive assessment (NEE form).

Clinical Data/Diagnostic Studies/Neurocognitive
ecg_maj
Major ECG Abnormalities
Major ECG Abnormalities

This variable is defined only for participants that have ECG data.

Clinical Data/Diagnostic Studies/Neurocognitive
ecg_min
Minor ECG Abnormalities
Minor ECG Abnormalities

This variable is defined only for participants that have ECG data.

Clinical Data/Diagnostic Studies/Neurocognitive
no_disability_6item
No Diability on NEEA5-7
No Diability on NEEA5-7 Clinical Data/Diagnostic Studies/Neurocognitive
sevlt_3trials
SEVTL, Sum of 3 Trials (NEEA8=10)
SEVTL, Sum of 3 Trials (NEEA8=10)

This variable is the sum of the scores of the first 3 trials of the SEVLT test. Only defined for participants who took a neurocognitive assessment (NEE form).

Clinical Data/Diagnostic Studies/Neurocognitive
sevlt_recall
SEVLT, Delay Recall (NEEA11 with re-coding)
SEVLT, Delay Recall (NEEA11 with re-coding)

This variable is the scores of the 5th delayed recall trial of the SEVLT test. Definition per Dr. Hector Gonzalez. Only defined for participants who took a neurocognitive assessment (NEE form).

Clinical Data/Diagnostic Studies/Neurocognitive
total_6item
Total Score on 6 Item Screener (with re-coding)
Total Score on 6 Item Screener (with re-coding)

This variable is the total score of the 6-item screener, which uses recoding of the original responses per definitions by Dr. Hector Gonzalez. It can take integer values from 0 to 6. Only defined for participants who took a neurocognitive assessment (NEE form).

Clinical Data/Diagnostic Studies/Neurocognitive
wordfreq
Word Frequency (A+F) (NEEA12-13)
Word Frequency (A+F) (NEEA12-13)

This variable is the sum of the score of the A and F parts of the Word Fluency test. Only defined for participants who took a neurocognitive assessment (NEE form).

Clinical Data/Diagnostic Studies/Neurocognitive
cdcr_sueno
Cerebrovascular Disease and Carotid Revascularization, self-reported at the Sueno clinic visit
Cerebrovascular Disease and Carotid Revascularization, self-reported at the Sueno clinic visit

This variable checks for medical history of stroke, mini-stroke or TIA, or balloon angioplasty or surgery to the arteries in the neck.

Clinical Data/Incident Outcomes
diabetes_self_sueno
Diabetes - self report only, collected during the sueno clinic visit
Diabetes - self report only, collected during the sueno clinic visit

This variable indicates a self-report of diabetes.

Clinical Data/Incident Outcomes
diabetes_sueno
Diabetes (at Sueno visit) derived from SOL diagnosis and Sueno diabetes mellitus variables
Diabetes (at Sueno visit) derived from SOL diagnosis and Sueno diabetes mellitus variables Clinical Data/Incident Outcomes
hypertension_sueno
Hypertension at the Sueno visit as derived from the SOL diagnosis and Sueno hypertension variables
Hypertension at the Sueno visit as derived from the SOL diagnosis and Sueno hypertension variables

Hypertension is defined here if the systolic or diastolic blood pressure is greater than or equal to 140/90 or if the participant is currently taking antihypertensive medications.

Clinical Data/Incident Outcomes
cardiac_risk_ratio
Cardiac Risk Ratio (TC/HDL) - AHA
Cardiac Risk Ratio (TC/HDL) - AHA

This variable calculates the ratio of total cholesterol by HDL cholesterol.

Clinical Data/Laboratory Tests
ckd
Chronic Kidney Disease using eGFR only (NIDDK)
Chronic Kidney Disease using eGFR only (NIDDK)

This variable estimated based on the estimated GFR value and is defined using NIDDK guidelines.

Clinical Data/Laboratory Tests
dyslipidemia
Dyslipidemia (High LDL, low HDL, or high triglyerides) - NIH
Dyslipidemia (High LDL, low HDL, or high triglyerides) - NIH

This variable checks for HDL, LDL, and triglyceride values to determine presence/absence of dyslipidemia.

Clinical Data/Laboratory Tests
gfrscr
eGFR based on serum creatinine, gender, age and race
eGFR based on serum creatinine, gender, age and race

This variable estimates Glomerular filtration rate, based on serum creatinine, and demographics gender, age and race (black vs. nonblack).

Clinical Data/Laboratory Tests
gfrscys
eGFR based on serum cystatin C w/o demographics
eGFR based on serum cystatin C w/o demographics

This variable estimates Glomerular filtration rate, based on serum cystatin C and no demographic factors.

Clinical Data/Laboratory Tests
gfrscys_scr
eGFR based on serum cystatin C, serum creatinine, gender, age, and race
eGFR based on serum cystatin C, serum creatinine, gender, age, and race

This variable estimates Glomerular filtration rate, based on serum cystatin C, serum creatinine, and demographics gender, age and race (black vs. nonblack).

Clinical Data/Laboratory Tests
hba1c_si
Glycosylated Hemoglobin (HbA1c) in SI units (mmol/mol), nearest integer
Glycosylated Hemoglobin (HbA1c) in SI units (mmol/mol), nearest integer Clinical Data/Laboratory Tests