Cleveland Family Study

What

Family-based study on quantifying the familial aggregation of sleep apnea.

Who

2,284 individuals from 361 families.

When

Five visits over a 16 year period (1990-2006).

Funding

National Institutes of Health

About

The Cleveland Family Study (CFS) is the largest family-based study of sleep apnea worldwide, consisting of 2,284 individuals (46% African American) from 361 families studied on up to 4 occasions over a period of 16 years. The study was begun in 1990 with the initial aims of quantifying the familial aggregation of sleep apnea. NIH renewals provided expansion of the original cohort (including increased minority recruitment) and longitudinal follow-up, with the last exam occurring in February 2006.

Note: Data from CFS Visit 5 (i.e. the last exam) will be posted to the NSRR first. Visit 5 included full overnight PSG. Data from prior CFS visits will be posted in the future.

Data overview

/datasets (introduction)
Core data from Cleveland Family Study.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from Cleveland Family Study.

Protocols and manuals

Equipment

EEG Spectral Analysis

As part of the NSRR's effort to explore the CFS data in more detail, EEG spectral analysis was performed. Read more about the methods, validation, and results for the NSRR EEG spectral analysis efforts. Summary datasets are available and the included variables can be browsed here.

Recent changes

Publication links

Citation

When citing this dataset please use:

  1. Dean, D. A., Goldberger, A. L., Mueller, R., Kim, M., Rueschman, M., Mobley, D., Sahoo, S. S., Jayapandian, C. P., Cui, L., Morrical, M. G., Surovec, S., Zhang, G. Q., & Redline, S. (2016). Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep, 5, 1151–1164
  2. Redline, S., Tishler, P. V., Tosteson, T. D., Williamson, J., Kump, K., Browner, I., Ferrette, V., & Krejci, P. (1995). The familial aggregation of obstructive sleep apnea. American journal of respiratory and critical care medicine, 3 Pt 1, 682–687.
  3. Redline, S., Tishler, P. V., Schluchter, M., Aylor, J., Clark, K., & Graham, G. (1999). Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. American journal of respiratory and critical care medicine, 5 Pt 1, 1527–1532.

Supported by grants (HL46380, M01 RR00080-39, T32-HL07567, RO1-46380) from the National Institutes of Health.