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Cleveland Family Study


Family-based study on quantifying the familial aggregation of sleep apnea.


2,284 individuals from 361 families.


Five visits over a 16 year period (1990-2006).


National Institutes of Health


The Cleveland Family Study (CFS) is the largest family-based study of sleep apnea worldwide, consisting of 2,284 individuals (46% African American) from 361 families studied on up to 4 occasions over a period of 16 years. The study was begun in 1990 with the initial aims of quantifying the familial aggregation of sleep apnea. NIH renewals provided expansion of the original cohort (including increased minority recruitment) and longitudinal follow-up, with the last exam occurring in February 2006.

Note: Data from CFS Visit 5 (i.e. the last exam) will be posted to the NSRR first. Visit 5 included full overnight PSG. Data from prior CFS visits will be posted in the future.

Data access restrictions

The Cleveland Family Study (CFS) dataset is only available for non-commercial use.

Citation and acknowledgement

When using this dataset, please cite the following:

Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358. doi: 10.1093/jamia/ocy064. PMID: 29860441; PMCID: PMC6188513.

Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, Browner I, Ferrette V, Krejci P. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):682-7. doi: 10.1164/ajrccm/151.3_Pt_1.682. PMID: 7881656.

Please include the following text in the Acknowledgements:

The Cleveland Family Study (CFS) was supported by grants from the National Institutes of Health (HL46380, M01 RR00080-39, T32-HL07567, RO1-46380). The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).

Data overview

/datasets (introduction)
Core data from Cleveland Family Study.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from Cleveland Family Study.

Protocols and manuals


Recent changes

Publication links

National Sleep Research Resource
Cleveland Family Study