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Cleveland Family Study


Family-based study on quantifying the familial aggregation of sleep apnea.


2,284 individuals from 361 families.


Five visits over a 16 year period (1990-2006).


National Institutes of Health


The Cleveland Family Study (CFS) is the largest family-based study of sleep apnea worldwide, consisting of 2,284 individuals (46% African American) from 361 families studied on up to 4 occasions over a period of 16 years. The study was begun in 1990 with the initial aims of quantifying the familial aggregation of sleep apnea. NIH renewals provided expansion of the original cohort (including increased minority recruitment) and longitudinal follow-up, with the last exam occurring in February 2006.

Note: Data from CFS Visit 5 (i.e. the last exam) will be posted to the NSRR first. Visit 5 included full overnight PSG. Data from prior CFS visits will be posted in the future.

Data overview

/datasets (introduction)
Core data from Cleveland Family Study.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from Cleveland Family Study.

Protocols and manuals


Recent changes

Publication links


When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.
  3. Redline S, Tishler PV, Tosteson TD, Williamson J, Kump K, Browner I, Ferrette V, Krejci P. The familial aggregation of obstructive sleep apnea. Am J Respir Crit Care Med. 1995 Mar;151(3 Pt 1):682-7. PubMed PMID: 7881656.
  4. Redline S, Tishler PV, Schluchter M, Aylor J, Clark K, Graham G. Risk factors for sleep-disordered breathing in children. Associations with obesity, race, and respiratory problems. Am J Respir Crit Care Med. 1999 May;159(5 Pt 1):1527-32. PubMed PMID: 10228121.

Supported by grants (HL46380, M01 RR00080-39, T32-HL07567, RO1-46380) from the National Institutes of Health.

National Sleep Research Resource
Cleveland Family Study