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Best Apnea Interventions in Research


A planning study to address challenges in conducting future large-scale trials of sleep apnea treatment.


Sleep apnea patients with cardiovascular disease or risk factors.


2011-2014, subjects had two or three visits – baseline, 6-month, and/or 12-month follow-up.


National Heart, Lung, and Blood Institute and ResMed Foundation.


The Best Apnea Interventions for Research (BestAIR) study aimed to randomize approximately 180 patients with sleep apnea who had either established CVD or at least three CVD risk factors into a 12-mo, four-arm intervention study. All arms included nightly use of nasal dilator strips and conservative medical therapy (CMT) defined as education on healthy sleep and lifestyle. The two active arms were: (1) active CPAP delivered using standard support from a trained sleep technician; and (2) active CPAP enhanced by a behavioral promotion intervention delivered by a behavioral therapist. The two control arms were: (1) sham-CPAP; and (2) CMT alone. The primary physiological outcome was change in mean 24-h systolic blood pressure. Process measures were recruitment yields, retention rates, and CPAP adherence levels.

Read more about BestAIR at ClinicalTrials.gov (NCT01261390).

Data overview

/datasets (introduction)
Core data from baseline and follow-up visits.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from baseline and follow-up visits.

Protocols and manuals


Recent Changes


When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.
  3. Gleason K, Shin D, Rueschman M, Weinstock T, Wang R, Ware JH, Mittleman MA, Redline S. Challenges in recruitment to a randomized controlled study of cardiovascular disease reduction in sleep apnea: an analysis of alternative strategies. Sleep. 2014 Dec 1;37(12):2035-8. doi: 10.5665/sleep.4266. PubMed PMID: 25325506; PubMed Central PMCID: PMC4548521.

This study was supported by NIH NHLBI [Grant 1U34HL105277] and a grant from ResMed Foundation. Equipment was donated by ResMed and Philips Respironics.

National Sleep Research Resource
Best Apnea Interventions in Research