Best Apnea Interventions in Research

The National Sleep Research Resource (NSRR) subject identifier links the subject's data and files.

CMT consisted of education on sleep hygiene, healthy lifestyle, and nasal dilator strips for use during sleep. ME consisted of a behavioral intervention to improve CPAP adherence, as described in Bakker et al.2017 (PMCID: PMC4980541).

Randomized participants were stratified by site. The site location has been recoded because it is an identifier.

Summary score for Patient Health Questionnaire 8-item. Kroenke K et al. 2001 (PubMED ID: 11556941)

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Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: bmi at Baseline

Average resting diastolic blood pressure of three measurements collected from the upper arm in a single clinic visit. In cases where either of the measurements was missing, the average was calculated discarding the missing value.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: avgseateddiastolic at Baseline

Average resting systolic blood pressure of three measurements collected from the upper arm in a single clinic visit. In cases where either of the measurements was missing, the average was calculated discarding the missing value.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: avgseatedsystolic at Baseline

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: age at Baseline

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: age at Baseline

Original missing value is recoded as "not reported".

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: ethnicity

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: race

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: gender

Indicates whether subject ever regularly smoked cigarettes.No means less than 20 packs in a lifetime or less than 1 cigarette for 1 year.

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: shq_eversmoked at Baseline

Harmonized by the NSRR team.

The definition of hypopnea events is consistent with the following clinical guidelines: (1) AASM 2012 update (alternative) Berry RB et al. 2012 (PubMed ID:23066376), and (2) AASM 2015 (acceptable) [Berry RB et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2. American Academy of Sleep Medicine, Darien, IL, 2015.].

Data collected with no EEGs. Refer to the source for detailed definition for respiratory events: ahi_primary

Calculated - Summary metric of sleep disordered breathing events. The definition of hypopnea events is consistent with the following clinical guidelines: (1) AASM 2012 update (alternative) Berry RB et al. 2012 (PubMed ID:23066376), and (2) AASM 2015 (acceptable) [Berry RB et al. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications, Version 2.2. American Academy of Sleep Medicine, Darien, IL, 2015.].

Estimated sleep duration, providing an approximation of total sleep duration (i.e. total sleep time) inferred from analysis of non-EEG channels Zhao et al., 2017 (PMID:27707441) In-bed period is the interval between lights off/in-bed time and lights on/out-bed time. Conventionally, this variable could be described as the ratio between total sleep time (TST) and time in bed (TIB).

Calculated - Total score based on an 8-item questionnaires ranking likelihood of dozing off Johns MW 1991 (PubMed ID: 1798888). Scale 0-3 for individual items; 0 to 24 for overall score.

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Calculated - Summary score for the PROMIS Sleep Disturbance instrument. Each item ranges from 1 to 5. The raw score is the sum of 8 items, and the T-score is identified by looking up total raw score in a T-score table. The T-score is categorized as: <55 (none to slight), 55.0 to 59.9 (mild), 60.0 to 69.9 (moderate), and >=70 (severe). Yu L et al, 2012 (PMID: 22250775)

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Summary score for the PROMIS Sleep-Related Impairment instrument. Each item ranges from 1 to 5. The total score is derived by summing all 8 items and divided by the number of answered items. Higher score indicates more severe sleep related impairment.Yu L et al, 2012 (PMID: 22250775)

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Calculated - The Women's Health Initiative Insomnia Rating Scale (WHIIRS) has 5 items. Each item is scored on a 5 point scale (from 0-4). The total score is the sum of all five items ranging from 0 to 20. Higher score indicates more severe insomnia. A score of 9 or higher is considered clinically significant insomnia. Levine et al.(2003)

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Summary component score of mental health. Taft C et al. 2001 (PubMED ID: 11763202)

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Summary component score of physical health. Taft C et al. 2001 (PubMED ID: 11763202)

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