Sleep Heart Health Study

What

Multi-cohort study focused on sleep-disordered breathing and cardiovascular outcomes.

Who

5,804 adults aged 40 and older.

When

Two exam cycles, 1995-1998 and 2001-2003. Cardiovascular disease outcomes were tracked until 2010.

Funding

National Heart, Lung, and Blood Institute

About

The Sleep Heart Health Study (SHHS) is a multi-center cohort study implemented by the National Heart Lung & Blood Institute to determine the cardiovascular and other consequences of sleep-disordered breathing. It tests whether sleep-related breathing is associated with an increased risk of coronary heart disease, stroke, all cause mortality, and hypertension.  In all, 6,441 men and women aged 40 years and older were enrolled between November 1, 1995 and January 31, 1998 to take part in SHHS Visit 1. During exam cycle 3 (January 2001- June 2003), a second polysomnogram (SHHS Visit 2) was obtained in 3,295 of the participants. CVD Outcomes data were monitored and adjudicated by parent cohorts between baseline and 2011. More than 130 manuscripts have been published investigating predictors and outcomes of sleep disorders. Click here for a full description of SHHS.

Read more about SHHS at ClinicalTrials.gov (NCT00005275).

Data overview

/datasets (introduction)
Core data from SHHS Visit 1 and Visit 2, as well as longitudinal CVD Outcomes tracking.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from SHHS Visit 1 and Visit 2.

Protocols and manuals

Analysis

Equipment

EEG Spectral Analysis

As part of the NSRR's effort to explore the SHHS data in more detail, EEG spectral analysis was performed. Read more about the methods, validation, and results for the NSRR EEG spectral analysis efforts. Summary datasets are available and the included variables can be browsed here.

Heart Rate Variability (HRV) Analysis

Read about the methods, validation, and results for the NSRR HRV analysis efforts. There are summary datasets available and the included variables can be browsed here.

Recent changes

Publication links

Citation

When citing this dataset please use:

  1. Dean, D. A., Goldberger, A. L., Mueller, R., Kim, M., Rueschman, M., Mobley, D., Sahoo, S. S., Jayapandian, C. P., Cui, L., Morrical, M. G., Surovec, S., Zhang, G. Q., & Redline, S. (2016). Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep, 5, 1151–1164
  2. Quan, S. F., Howard, B. V., Iber, C., Kiley, J. P., Nieto, F. J., O'Connor, G. T., Rapoport, D. M., Redline, S., Robbins, J., Samet, J. M., & Wahl, P. W. (1997). The Sleep Heart Health Study: design, rationale, and methods. Sleep, 12, 1077–1085.
  3. Redline, S., Sanders, M. H., Lind, B. K., Quan, S. F., Iber, C., Gottlieb, D. J., Bonekat, W. H., Rapoport, D. M., Smith, P. L., & Kiley, J. P. (1998). Methods for obtaining and analyzing unattended polysomnography data for a multicenter study. Sleep Heart Health Research Group. Sleep, 7, 759–767.

Supported by grants (U01HL53916, U01HL53931, U01HL53934, U01HL53937, U01HL53938, U01HL53940, U01HL53941, U01HL64360) from the National Institutes of Health.