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Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be


A prospective cohort study of women pregnant for the first time


10,038 women, with 3,702 participating in the sleep-disordered breathing substudy


2011 to 2013, with two visits during pregnancy for each participant




The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b), which began in 2010, studies pregnant women who will be delivering for the first time (nulliparous women). This prospective cohort study evaluates the underlying, interrelated mechanisms of several common adverse pregnancy outcomes, which can be unpredictable in women who have little or no pregnancy history, to help guide their treatment. This initiative addresses a critical group of at-risk women who are currently understudied and represent 40% of U.S. births each year. The results of this study will help inform healthcare providers and their patients who are pregnant or considering pregnancy and will support future research to improve care and outcomes in this group of women.

The study was initiated by NICHD's Pregnancy and Perinatology Branch and is primarily funded by NICHD, with co-funding from the NIH Office of Research on Women's Health. A National Heart, Lung, and Blood Institute-funded substudy of 3,600 nuMoM2b participants is examining the relationship between sleep disorders during pregnancy and adverse pregnancy outcomes.

Additional nuMoM2b data are available at NICHD's DASH resource.

Citation and acknowledgement

When using this dataset, please cite the following:

Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358. doi: 10.1093/jamia/ocy064. PMID: 29860441; PMCID: PMC6188513.

Facco FL, Parker CB, Reddy UM, Silver RM, Louis JM, Basner RC, Chung JH, Schubert FP, Pien GW, Redline S, Mobley DR, Koch MA, Simhan HN, Nhan-Chang CL, Parry S, Grobman WA, Haas DM, Wing DA, Mercer BM, Saade GR, Zee PC. NuMoM2b Sleep-Disordered Breathing study: objectives and methods. Am J Obstet Gynecol. 2015 Apr;212(4):542.e1-127. doi: 10.1016/j.ajog.2015.01.021. Epub 2015 Mar 4. PMID: 25746730; PMCID: PMC4410772.

Please include the following text in the Acknowledgements:

The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be was supported by grant funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Heart, Lung, and Blood Institute: U10 HD063036, Research Triangle Institute; U10 HD063072, Case Western Reserve University; U10 HD063047, Columbia University; U10 HD063037, Indiana University; U10 HD063041, Magee-Women's Hospital; U10 HD063020, Northwestern University; U10 HD063046, University of California Irvine; U10 HD063048, University of Pennsylvania; and U10 HD063053, University of Utah. The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).

Data overview

/datasets (introduction)
Core data and home sleep testing results.

/polysomnography (introduction)
Raw physiological data and scoring annotations from home sleep testing.

Protocols and manuals



Please reach out to us at support@sleepdata.org or in the Forum if you have questions.

National Sleep Research Resource
Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-be