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Home Positive Airway Pressure

What

Randomized, multicenter clinical trial comparing home-based and in-laboratory polysomnography (PSG) for diagnosis and titration

Who

Adult patients referred to a sleep center with a high pretest probability of moderate to severe OSA

When

2008-2010, subjects had baseline and two follow-up visits

Funding

American Sleep Medicine Foundation

About

The Home Positive Airway Pressure (HomePAP) study was a multisite, nonblinded, randomized controlled trial that enrolled 373 patients at seven American Academy of Sleep Medicine (AASM)-accredited academic sleep centers with a high pretest probability of moderate to severe OSA (based on a clinical algorithm). Eligible subjects were evaluated in clinic and randomized to one of two management pathways: 1) laboratory-based and 2) home-based. All subjects with an AHI ≥ 15 who underwent a successful CPAP titration study were offered CPAP therapy. Subjects were re-evaluated in clinic after 1- and 3-month follow-up periods.

Read more about HomePAP at ClinicalTrials.gov (NCT00642486).

Citation and acknowledgement

When using this dataset, please cite the following:

Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 Oct 1;25(10):1351-1358. doi: 10.1093/jamia/ocy064. PMID: 29860441; PMCID: PMC6188513.

Rosen CL, Auckley D, Benca R, Foldvary-Schaefer N, Iber C, Kapur V, Rueschman M, Zee P, Redline S. A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea: the HomePAP study. Sleep. 2012 Jun 1;35(6):757-67. doi: 10.5665/sleep.1870. PMID: 22654195; PMCID: PMC3353048.

Please include the following text in the Acknowledgements:

The Home Positive Airway Pressure study (HomePAP) was supported by the American Sleep Medicine Foundation 38-PM-07 Grant: Portable Monitoring for the Diagnosis and Management of OSA. The National Sleep Research Resource was supported by the National Heart, Lung, and Blood Institute (R24 HL114473, 75N92019R002).

Data overview

/datasets (introduction)
Core data from the baseline and follow-up visits.

/polysomnography (introduction)
Overnight home- and lab-based polysomnography (PSG) data from the baseline visit.

Protocols and manuals

Equipment

Recent changes

National Sleep Research Resource
Home Positive Airway Pressure