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Home Positive Airway Pressure


Randomized, multicenter clinical trial comparing home-based and in-laboratory polysomnography (PSG) for diagnosis and titration


Adult patients referred to a sleep center with a high pretest probability of moderate to severe OSA


2008-2010, subjects had baseline and two follow-up visits


American Sleep Medicine Foundation


The Home Positive Airway Pressure (HomePAP) study was a multisite, nonblinded, randomized controlled trial that enrolled 373 patients at seven American Academy of Sleep Medicine (AASM)-accredited academic sleep centers with a high pretest probability of moderate to severe OSA (based on a clinical algorithm). Eligible subjects were evaluated in clinic and randomized to one of two management pathways: 1) laboratory-based and 2) home-based. All subjects with an AHI ≥ 15 who underwent a successful CPAP titration study were offered CPAP therapy. Subjects were re-evaluated in clinic after 1- and 3-month follow-up periods.

Read more about HomePAP at ClinicalTrials.gov (NCT00642486).

Data overview

/datasets (introduction)
Core data from the baseline and follow-up visits.

/polysomnography (introduction)
Overnight home- and lab-based polysomnography (PSG) data from the baseline visit.

Protocols and manuals


Recent changes


When citing this dataset please use:

  1. Dean DA 2nd, Goldberger AL, Mueller R, Kim M, Rueschman M, Mobley D, Sahoo SS, Jayapandian CP, Cui L, Morrical MG, Surovec S, Zhang GQ, Redline S. Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep. 2016 May 1;39(5):1151-64. doi: 10.5665/sleep.5774. Review. PubMed PMID: 27070134; PubMed Central PMCID: PMC4835314.
  2. Zhang GQ, Cui L, Mueller R, Tao S, Kim M, Rueschman M, Mariani S, Mobley D, Redline S. The National Sleep Research Resource: towards a sleep data commons. J Am Med Inform Assoc. 2018 May 31. doi: 10.1093/jamia/ocy064. [Epub ahead of print] PubMed PMID: 29860441.
  3. Rosen CL, Auckley D, Benca R, Foldvary-Schaefer N, Iber C, Kapur V, Rueschman M, Zee P, Redline S. A multisite randomized trial of portable sleep studies and positive airway pressure autotitration versus laboratory-based polysomnography for the diagnosis and treatment of obstructive sleep apnea: the HomePAP study. Sleep. 2012 Jun 1;35(6):757-67. doi: 10.5665/sleep.1870. PubMed PMID: 22654195; PubMed Central PMCID: PMC3353048.

Support provided by American Sleep Medicine Foundation 38-PM-07 Grant: Portable Monitoring for the Diagnosis and Management of OSA.

National Sleep Research Resource
Home Positive Airway Pressure