Childhood Adenotonsillectomy Trial


Multi-center randomized trial comparing early adenotonsillectomy to watchful waiting plus supportive care.


464 children aged 5-9.9 years with mild to moderate obstructive sleep apnea.


2007-2012, subjects had two visits – baseline and 7-month follow-up.


National Heart, Lung, and Blood Institute

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The Childhood Adenotonsillectomy Trial (CHAT) is a multi-center, single-blind, randomized, controlled trial designed to test whether after a 7-month observation period, children, ages 5 to 9.9 years, with mild to moderate obstructive sleep apnea randomized to early adenotonsillectomy (eAT) will show greater levels of neurocognitive functioning, specifically in the attention-executive functioning domain, than children randomized to watchful waiting plus supportive care (WWSC). Other outcomes assessed included other indices of neurocognitive functioning (learning and memory, information processing, etc.), physical growth, blood pressure, metabolic profile, symptoms and quality of life. Physiological measures of sleep were assessed at baseline and at 7-months with standardized full polysomnography with central scoring at the Brigham and Women’s Sleep Reading Center. In total, 1,447 children had screening polysomnographs and 464 were randomized to treatment.

Read more about CHAT at (NCT00560859).

Data overview

/datasets (introduction)
Core data from the CHAT study.

/polysomnography (introduction)
Overnight polysomnography (PSG) data from the CHAT study.

Protocols and manuals



EEG Spectral Analysis

As part of the NSRR's effort to explore the CHAT data in more detail, EEG spectral analysis was performed. Read more about the methods, validation, and results for the NSRR EEG spectral analysis efforts. There are two summary datasets available and the included variables can be browsed here.

Heart Rate Variability (HRV) Analysis

Read about the methods, validation, and results for the NSRR HRV analysis efforts. There are summary datasets available and the included variables can be browsed here.

Thoraco-Abdominal Asynchrony Analysis (TAA)

NSRR user Mathias Baumert and colleagues conducted a specialized analysis using the CHAT polysomnography data. TAA result variables have been added to the baseline and follow-up datasets.

Read more about the results and methods in their publication.

Recent changes

Publication links


When citing this dataset please use:

  1. Dean, D. A., Goldberger, A. L., Mueller, R., Kim, M., Rueschman, M., Mobley, D., Sahoo, S. S., Jayapandian, C. P., Cui, L., Morrical, M. G., Surovec, S., Zhang, G. Q., & Redline, S. (2016). Scaling Up Scientific Discovery in Sleep Medicine: The National Sleep Research Resource. Sleep, 5, 1151–1164
  2. Redline, S., Amin, R., Beebe, D., Chervin, R. D., Garetz, S. L., Giordani, B., Marcus, C. L., Moore, R. H., Rosen, C. L., Arens, R., Gozal, D., Katz, E. S., Mitchell, R. B., Muzumdar, H., Taylor, H. G., Thomas, N., & Ellenberg, S. (2011). The Childhood Adenotonsillectomy Trial (CHAT): rationale, design, and challenges of a randomized controlled trial evaluating a standard surgical procedure in a pediatric population. Sleep, 11, 1509–1517.
  3. Marcus, C. L., Moore, R. H., Rosen, C. L., Giordani, B., Garetz, S. L., Taylor, H. G., Mitchell, R. B., Amin, R., Katz, E. S., Arens, R., Paruthi, S., Muzumdar, H., Gozal, D., Thomas, N. H., Ware, J., Beebe, D., Snyder, K., Elden, L., Sprecher, R. C., Willging, P., Jones, D., Bent, J. P., Hoban, T., Chervin, R. D., Ellenberg, S. S., Redline, S., & , . (2013). A randomized trial of adenotonsillectomy for childhood sleep apnea. The New England journal of medicine, 25, 2366–2376.

Supported by grants (HL083075, HL083129, UL1-RR-024134, UL1 RR024989) from the National Institutes of Health.