Multi-center randomized trial comparing early adenotonsillectomy to watchful waiting plus supportive care.
464 children aged 5-9.9 years with mild to moderate obstructive sleep apnea.
2007-2012, subjects had two visits – baseline and 7-month follow-up.
National Heart, Lung, and Blood Institute
The Childhood Adenotonsillectomy Trial (CHAT) is a multi-center, single-blind, randomized, controlled trial designed to test whether after a 7-month observation period, children, ages 5 to 9.9 years, with mild to moderate obstructive sleep apnea randomized to early adenotonsillectomy (eAT) will show greater levels of neurocognitive functioning, specifically in the attention-executive functioning domain, than children randomized to watchful waiting plus supportive care (WWSC). Other outcomes assessed included other indices of neurocognitive functioning (learning and memory, information processing, etc.), physical growth, blood pressure, metabolic profile, symptoms and quality of life. Physiological measures of sleep were assessed at baseline and at 7-months with standardized full polysomnography with central scoring at the Brigham and Women’s Sleep Reading Center. In total, 1,447 children had screening polysomnographs and 464 were randomized to treatment.
Read more about CHAT at ClinicalTrials.gov (NCT00560859).
As part of the NSRR's effort to explore the CHAT data in more detail, EEG spectral analysis was performed. Read more about the methods, validation, and results for the NSRR EEG spectral analysis efforts. There are two summary datasets available and the included variables can be browsed here.
Read about the methods, validation, and results for the NSRR HRV analysis efforts. There are summary datasets available and the included variables can be browsed here.
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Supported by grants (HL083075, HL083129, UL1-RR-024134, UL1 RR024989) from the National Institutes of Health.