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Sleep Disordered Breathing, ApoE and Lipid Metabolism

Name Label Folder
nsrr_bmi
Body mass index (BMI)
Body mass index (BMI)

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: bmi

Harmonized/Anthropometry
nsrr_age
Subject age
Subject age

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: age

Harmonized/Demographics
nsrr_age_gt89
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years
Indicates whether the subject's age (in years) used during date obfuscation is greater than 89 years

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: age

Harmonized/Demographics
nsrr_sex
Subject sex
Subject sex

Harmonized by the NSRR team to align with TOPMed and BioDataCatalyst standards. Source: gender

Harmonized/Demographics
nsrr_pctdursp_s1
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 1 from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 1 from polysomnography

Harmonized by the NSRR team. Source: pct_s1

Harmonized/Polysomnography/Sleep Architecture
nsrr_pctdursp_s2
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 2 from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 2 from polysomnography

Harmonized by the NSRR team. Source: pct_s2

Harmonized/Polysomnography/Sleep Architecture
nsrr_pctdursp_s3
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 3/4 from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in stage 3/4 from polysomnography

Harmonized by the NSRR team. Source: pct_s3

Harmonized/Polysomnography/Sleep Architecture
nsrr_pctdursp_sr
Percentage of total sleep duration (i.e., total sleep time, TST) in REM from polysomnography
Percentage of total sleep duration (i.e., total sleep time, TST) in REM from polysomnography

Harmonized by the NSRR team. Source: pct_sr

Harmonized/Polysomnography/Sleep Architecture
nsrr_tib_f1
Total period of bed (i.e., time in bed) from polysomnography
Total period of bed (i.e., time in bed) from polysomnography

Harmonized by the NSRR team. Source: tib

Harmonized/Polysomnography/Sleep Architecture
nsrr_tst_f1
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from polysomnography
Total Sleep Duration: the interval between sleep onset and sleep offset while the participant is asleep from polysomnography

Conventionally, this would be called total sleep time (TST) (i.e., total time spent in stage 1 or greater).

Harmonized by the NSRR team. Source: tst

Harmonized/Polysomnography/Sleep Architecture
nsrr_ttleffsp_f1
Sleep Efficiency: the ratio of total sleep duration (i.e., total sleep time) to in-bed period (i.e., time in bed) from polysomnography
Sleep Efficiency: the ratio of total sleep duration (i.e., total sleep time) to in-bed period (i.e., time in bed) from polysomnography

Harmonized by the NSRR team. Source: sleep_efficiency

Harmonized/Polysomnography/Sleep Architecture
apoe_edf_date
Date and start time of the polysomnogram
Date and start time of the polysomnogram

Date and start time of the PSG as listed n the EDF file's header. Note: the start date has been deidentified to the first day of that month the PSG conducted.

Administrative
apoe_edf_label
The EDF header's label entry
The EDF header's label entry

This corresponds to the filestem and adds some redundancy to identifying the EDF file in case the filename was accidentally changed.

Administrative
apoe_filename
File stem of the polysomnography file (.edf)
File stem of the polysomnography file (.edf) Administrative
apoe_id
Unique identifier of the APoE participant
Unique identifier of the APoE participant

Unique identifier of the APoE participant

Administrative
visit
Study Visit
Study Visit Administrative
bmi
Body Mass index (BMI)
Body Mass index (BMI) Anthropometry
height
Height
Height Anthropometry
hip_cm
Hip circumference
Hip circumference Anthropometry
neck_cm
Neck circumference
Neck circumference Anthropometry
waist_cm
Waist circumference
Waist circumference Anthropometry
weight
Weight
Weight Anthropometry
ace_genotype
Angiotensin-Converting Enzyme (ACE) genotype
Angiotensin-Converting Enzyme (ACE) genotype

Read more about the ACE gene at MedlinePlus

Clinical Data/Genotyping
apoe_genotype
Apolipoprotein E (ApoE) genotype
Apolipoprotein E (ApoE) genotype

Read more about the ApoE gene at MedlinePlus

Clinical Data/Genotyping
dq0602_genotype
Presence of HLA-DQB1*06:02 allele
Presence of HLA-DQB1*06:02 allele

Read more about the HLA-DQB1 gene at MedlinePlus

Clinical Data/Genotyping
glucose
Glucose level
Glucose level Clinical Data/Laboratory Tests
hdl
HDL level
HDL level

HDL (high-density lipoprotein) cholesterol

Clinical Data/Laboratory Tests
ldl
LDL level
LDL level

LDL (low-density lipoprotein) cholesterol

Clinical Data/Laboratory Tests
total_choleserol
Total cholesterol level
Total cholesterol level Clinical Data/Laboratory Tests
triglycerides
Triglyceride level
Triglyceride level Clinical Data/Laboratory Tests
vldl
VLDL level
VLDL level

VLDL (very-low-density lipoprotein) level

Clinical Data/Laboratory Tests
dx_1st
Primary diagnosis
Primary diagnosis Clinical Data/Sleep Disorder
dx_2nd
Secondary diagnosis
Secondary diagnosis Clinical Data/Sleep Disorder
dx_3rd
Tertiary diagnosis
Tertiary diagnosis Clinical Data/Sleep Disorder
dx_other
Diagnosis if "Primary Diagnosis (dx_1st)" is "Other"
Diagnosis if "Primary Diagnosis (dx_1st)" is "Other" Clinical Data/Sleep Disorder
rls_phenotype
Classification of RLS
Classification of RLS

Unlikely when rls_disturbed_sleep = 1, 2, or 3 and rls_disturbed_sleep = 1 or 2; Likely when rls_disturbed_sleep =4 or 5 and rls_disturbed_sleep = 4 or 5

Clinical Data/Sleep Disorder
rls_probability
Probability of RLS
Probability of RLS

Control when rls_sleep_onset = 1, 2, or 3 and rls_disturbed_sleep = 1 or 2; Probable when rls_sleep_onset = 4 or 5 and rls_disturbed_sleep = 3; Definite when rls_sleep_onset = 4 or 5 and rls_disturbed_sleep = 4 or 5; Possible when any other combination

Clinical Data/Sleep Disorder
diabp
Diastolic blood pressure
Diastolic blood pressure Clinical Data/Vital Signs/Seated Blood Pressure
sysbp
Systolic blood pressure
Systolic blood pressure Clinical Data/Vital Signs/Seated Blood Pressure
age
Age
Age Demographics
gender
Gender
Gender Demographics
asthma
Diagnosis of asthma
Diagnosis of asthma Medical History
depression
Diagnosis of depression
Diagnosis of depression Medical History
diabetes
Diagnosis of diabetes
Diagnosis of diabetes Medical History
gerd
Diagnosis of gastroesophageal reflux disease (GERD)
Diagnosis of gastroesophageal reflux disease (GERD) Medical History
high_cholesterol
Diagnosis of high cholesterol
Diagnosis of high cholesterol Medical History
htn
Diagnosis of hypertension
Diagnosis of hypertension Medical History
observations
Doctor's notes/observations
Doctor's notes/observations Medical History
thyroid
Diagnosis of thyroid problems
Diagnosis of thyroid problems Medical History
current_med
Medication list at the time of evaluation
Medication list at the time of evaluation Medical History/Medications
plmindex
Periodic limb movement index - Number of periodic limb movement per hour of sleep from type I polysomnography
Periodic limb movement index - Number of periodic limb movement per hour of sleep from type I polysomnography Sleep Monitoring/Polysomnography/Limb Movements
odi3evindex
Oxygen Desaturation Index: Oxygen desaturation with >= 3% desat per hour of sleep from type I polysomnography
Oxygen Desaturation Index: Oxygen desaturation with >= 3% desat per hour of sleep from type I polysomnography

Derived using automated detection methods described in Koch et al. 2017.

Sleep Monitoring/Polysomnography/Oxygen Saturation
odi3evtotal
Total number of oxygen desaturation with >= 3% desat during sleep from type I polysomnography
Total number of oxygen desaturation with >= 3% desat during sleep from type I polysomnography

Derived using automated detection methods described in Koch et al. 2017.

Sleep Monitoring/Polysomnography/Oxygen Saturation
sao2_baseline
Baseline level of oxygen saturation from type I polysomnography
Baseline level of oxygen saturation from type I polysomnography Sleep Monitoring/Polysomnography/Oxygen Saturation
sao2_mean
Average oxygen saturation level during sleep from type I polysomnography
Average oxygen saturation level during sleep from type I polysomnography Sleep Monitoring/Polysomnography/Oxygen Saturation
sao2_min
Minimum oxygen saturation level during sleep from type I polysomnography
Minimum oxygen saturation level during sleep from type I polysomnography Sleep Monitoring/Polysomnography/Oxygen Saturation
pct_rem
Percentage of REM sleep among total sleep duration from type I polysomnography
Percentage of REM sleep among total sleep duration from type I polysomnography

Conventionally, total sleep duration would be called total sleep time (TST).

Sleep Monitoring/Polysomnography/Sleep Architecture
pct_s1
Percentage of stage 1 sleep among total sleep duration from type I polysomnography
Percentage of stage 1 sleep among total sleep duration from type I polysomnography

Conventionally, total sleep duration would be called total sleep time (TST).

Sleep Monitoring/Polysomnography/Sleep Architecture
pct_s2
Percentage of stage 2 sleep among total sleep duration from type I polysomnography
Percentage of stage 2 sleep among total sleep duration from type I polysomnography

Conventionally, total sleep duration would be called total sleep time (TST).

Sleep Monitoring/Polysomnography/Sleep Architecture
pct_s3
Percentage of stage 3 and 4 sleep among total sleep duration from type I polysomnography
Percentage of stage 3 and 4 sleep among total sleep duration from type I polysomnography

Conventionally, total sleep duration would be called total sleep time (TST).

Sleep Monitoring/Polysomnography/Sleep Architecture
psg_duration
Total period of recording from type I polysomnography
Total period of recording from type I polysomnography Sleep Monitoring/Polysomnography/Sleep Architecture
sleep_efficiency
Sleep Efficiency: the ratio of sleep duration (i.e., total sleep time) to in-bed period (i.e., time in bed) from type I polysomnography
Sleep Efficiency: the ratio of sleep duration (i.e., total sleep time) to in-bed period (i.e., time in bed) from type I polysomnography

Sleep duration is the interval between sleep onset time and lights on/out-bed time while asleep (i.e. total sleep time, TST), while in-bed period is the interval between lights off/in-bed time and lights on/out-bed time (i.e. time in bed, TIB). Percentage of time in bed that was spent sleeping, or the ratio of total sleep time to total time in bed, expressed as a percentage. Source: tst and tib

Sleep Monitoring/Polysomnography/Sleep Architecture
tib
Total In-bed Period: the interval between lights off/in-bed time and lights on/out-bed time from polysomnography
Total In-bed Period: the interval between lights off/in-bed time and lights on/out-bed time from polysomnography

Conventionally this variable would be called time in bed (TIB).

Sleep Monitoring/Polysomnography/Sleep Architecture
tst
Total Sleep Duration: the interval between sleep onset time and lights on/out-bed time while the participant is asleep from type I polysomnography
Total Sleep Duration: the interval between sleep onset time and lights on/out-bed time while the participant is asleep from type I polysomnography

Conventionally, this would be called total sleep time (TST) (i.e. total time spent in stage 1 or greater).

Sleep Monitoring/Polysomnography/Sleep Architecture
ess
Epworth Sleepiness Scale total score
Epworth Sleepiness Scale total score

Calculated - Total score based on an 8-item questionnaires ranking likelihood of dozing off Johns MW 1991 (PubMed ID: 1798888). Scale 0-3 for individual items; 0 to 24 for overall score.

Sleep Questionnaires/Hypersomnia
rls_disturbed_sleep
Frequency of RLS disturbed sleep
Frequency of RLS disturbed sleep Sleep Questionnaires/Parasomnia
rls_sleep_onset
Frequency of RLS symptoms while falling asleep
Frequency of RLS symptoms while falling asleep Sleep Questionnaires/Parasomnia